Heart Failure and Pulmonary Hypertension Research
Investigator-Initiated Research
| Principal Investigator | Study Title | Funding Agencies |
| Liviu Klein, MD | Early Feasibility Study of the Edwards Transcatheter Atrial Shunt System (ALT-FLOW) | Edwards Lifesciences |
| Mandar Aras, MD | Cardio-oncology and Cardiac Amyloid Retrospective Record Review Study | Internal Funding |
| Teresa De Marco, MD | Markers of Myocardial Stretch, circulating Endothelial Progenitor Cells, and Endothelial Function in Patients with Pulmonary Hypertension: Is there a Correlation with the Severity of Pulmonary Hypertension | Internal Funding |
| Teresa De Marco, MD | Investigation of characteristics of patients with PH at UCSF | Internal Funding |
| Teresa De Marco, MD | Correlation of invasive and non-invasive determinants of pulmonary vascular disease in patients with portopulmonary hypertension | Internal Funding |
| Teresa De Marco, MD | Advanced Heart Failure Retrospective Record Review Study | Internal Funding |
| Teresa De Marco, MD | Non-invasive pulmonary arterial capacitance, a novel screening tool for pulmonary hypertension. | Internal Funding |
| Kirsten Fleishmann, MD | Passive Smoke and Outcomes in Congestive Heart Failure | Flight Attendant Medical Research Institute |
| Kirsten Fleishmann, MD | Patients Preferences for Information about Statin Therapy | Internal Funding |
| Kirsten Fleishmann, MD | Physician Cholesterol Treatment Survey | Internal Funding |
| Liviu Klein, MD | HeartPulse for PreEclampsia: A pilot study of a modified bathroom scale to monitor heart function in pregnant women | NIH Natl Institute on Aging |
| Liviu Klein, MD | Advanced Heart Failure Retrospective Record Review Study | Internal Funding |
| Liviu Klein, MD | Hemodynamic assessment of left ventricular assist devices | Internal Funding |
| Liviu Klein, MD | An observational study to explore the use of portable device sensors as noninvasive assessment of arterial pressures and left ventricular filling pressures | Microsoft Corporation |
| Liviu Klein, MD | Right Ventricular Pacing to Treat Right Ventricular Failure | Internal Funding |
| Liviu Klein, MD | Tremolo: An observational study to explore the vibrations and sounds of the body that occur with each heart beat | NIH Natl Institute on Aging, NIH Natl Heart, Lung & Blood Institute |
| Liviu Klein, MD | An observational study to explore the vibrations and sounds of the body that occur with each heartbeat | NIH Natl Institute on Aging, NIH Natl Heart, Lung & Blood Institute |
| Liviu Klein, MD | Correlation Study of Sweat Compositions and Health Status Towards Wearable Health Monitoring Application | Internal Funding |
| Kirsten Tolstrup, MD | Clinical Utility of Pulmonary Vascular Resistance by Echocardiography in the Cardiovascular Evaluation of Liver Transplant Candidates | Internal Funding |
Clinical Trials
| Principal Investigator | Study Title | Funding Agencies |
| Ted Abraham, MD | Comparison of Respirix’s noninvasive Pulmonary Artery Compliance during and after decompensation in Heart Failure Patients | Respirix |
| Mandar Aras, MD | Destination Therapy (DT) Post Approval Study (PAS): Product Surveillance Registry (PSR) Platform | Medtronic |
| Mandar Aras, MD | PROACTIVE-HF: A Prospective, Multi-Center, Randomized, Controlled, Single Blind Clinical Trial Evaluating the Safety and Efficacy of the Cordella Pulmonary Artery Sensor System (CorPASS) in New York Heart Association (NYHA) Class III Heart Failure Patients | Endotronix |
| Mandar Aras, MD | A Prospective, Multi-Center, Randomized, Controlled, Single Blind Clinical Trial Evaluating the Safety and Efficacy of the Cordella™ Pulmonary Artery Sensor System in New York Heart Association (NYHA) Class III Heart Failure Patients | Endotronix |
| Richard Cheng, MD | TROPHY-II Trial Clinical evaluation of the Therapeutic Intra-Vascular Ultrasound (TIVUS™) System for pulmonary artery denervation in patients with pulmonary hypertension due to left heart disease | SoniVie Ltd. |
| Richard Cheng, MD | ASPIRE PH, Treatment of Pulmonary Artery Hypertension Using the Aria CV Pulmonary Hypertension System |
Aria CV, Inc |
| Teresa De Marco, MD | Surveillance HeartCare Outcomes Registry (SHORE) | CareDX |
| Liviu Klein, MD | Seeking Objectivity in Allocation of Advanced Heart Failure (SOCIAL HF) Therapies Trial | NIH |
| Liviu Klein, MD | Safety and effectiveness of the V-Wave Interatrial Shunt System to improve clinical outcomes in a certain high-risk subset of symptomatic patients suffering from HF. | V-Wave Medical |
| Liviu Klein, MD | Right Ventricular Pacing to Treat Right Ventricular Failure | UCSF Cardiology Innovation Award |
| Liviu Klein, MD | Remote Dielectric Sensing Technology Guided Diuresis in hospitalized patients with Acute Decompensated Heart Failure | Cardiology (Internal- UCSF) |
| Liviu Klein, MD | Urine biomarkers of kidney health during hospitalizations | Catalyst Grant |
| Liviu Klein, MD | RELEIVE-HF, Reducing lung congestion symptoms using the v-wavE Shunt in Advanced Heart Failure | V-Wave Ltd |
| Liviu Klein, MD | CORCINCH-HF Study: Randomized Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF) | Ancora Heart, Inc. |
| Marc Simon, MD | ARTISAN (Afterload Reduction To Improve Right Ventricular Structure And FuNction). A Phase 4, Prospective, Multicenter, Single-Arm Study of a Mean Pulmonary Artery Pressure-Targeted Approach with Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Patients with Pulmonary Arterial Hypertension | Lung Biotechnology PBC |
| Marc Simon, MD |
A Study of AV-101 (Dry Powder Inhaled Imatinib) in Patients With Pulmonary Arterial Hypertension (PAH) (IMPAHCT) |
Aerovate Therapeutics |
| Marc Simon, MD |
RELEIVE-PAH Trial, Reducing Right Ventricular Failure with the V-Wave Shunt in Pulmonary Arterial Hypertension |
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| Marc Simon, MD |
Phase II Trial of Metformin for Pulmonary Hypertension in Heart Failure with Preserved Ejection Fraction If you are interested in this study, please contact Dr. Marc Simon or Imani Robinson. |
NIH, National Institute on Aging |
| Marc Simon, MD |
Reducing Right Ventricular Failure with the V-Wave Shunt In Pulmonary Arterial Hypertension |
V-Wave Medical |