Shweta Motiwala, MD, MPH

Associate Professor

I am an Advanced Heart Failure and Transplant cardiologist, and the Director of Heart Failure Disease Management at UCSF. I have clinical expertise in evaluating and treating patients across the spectrum of heart failure disease severity, including those who require mechanical circulatory support or heart transplantation. I have a particular interest in developing chronic disease management programs to improve clinical outcomes and quality of life in patients with heart failure. These include initiatives to expand the use of remote monitoring technologies and platforms, to optimize the application of guideline-directed medical and device therapy, and to improve access to care and transitions of care.

My research interests include the use of biomarkers in understanding response to therapy and outcomes in heart failure, evaluation of novel remote monitoring and therapeutic devices, and approaches to improving delivery of care to broad patient populations.

Education
MPH, 2019 - Clinical Effectiveness, Harvard T.H. Chan School of Public Health
Fellowship, 2017 - Advanced Heart Failure and Transplant Cardiology, Brigham and Women's Hospital
Fellowship, 2016 - Cardiovascular Disease, Beth Israel Deaconess Medical Center
Residency, 2012 - Internal Medicine, Massachusetts General Hospital
MD, 2009 - Medicine, New York University School of Medicine
AB, 2004 - History and Science, Harvard College
Honors and Awards
  • Gerald E. Altman, MD and Harriet Altman Annual Cardiology Fellow Award (Clinical Excellence), Beth Israel Deaconess Medical Center, 2016
  • Dennis and Marilyn Barry Fellowship in Cardiovascular Medicine (Research), Massachusetts General Hospital, 2012-2013
  • AMWA Glasgow-Rubin Award (Academic Achievement), New York University School of Medicine, 2009
  • Alpha Omega Alpha Honor Society, New York University School of Medicine, 2008
  • Doris Duke Clinical Research Fellowship, Doris Duke Charitable Foundation, 2007-2008
Publications

  1. Writing Committee, Maddox TM, Januzzi JL, Allen LA, Breathett K, Brouse S, Butler J, Davis LL, Fonarow GC, Ibrahim NE, Lindenfeld J, Masoudi FA, Motiwala SR, Oliveros E, Walsh MN, Wasserman A, Yancy CW, Youmans QR. 2024 ACC Expert Consensus Decision Pathway for Treatment of Heart Failure With Reduced Ejection Fraction: A Report of the American College of Cardiology Solution Set Oversight Committee. Journal of the American College of Cardiology 2024. PMID: 38466244


  3. Gupta SK, Mostofsky E, Motiwala SR, Hage A, Mittleman MA. Induction immunosuppression and post-transplant diabetes mellitus: a propensity-matched cohort study. Frontiers in endocrinology 2023. PMID: 37929038


  4. Nunez JI, Grandin EW, Reyes-Castro T, Sabe M, Quintero P, Motiwala S, Fleming LM, Sriwattanakomen R, Ho JE, Kennedy K, Tonna JE, Garan AR. Outcomes With Peripheral Venoarterial Extracorporeal Membrane Oxygenation for Suspected Acute Myocarditis: 10-Year Experience From the Extracorporeal Life Support Organization Registry. Volume 16 of Issue 7. Circulation. Heart failure 2023. PMID: 37345545


  5. Ghajar A, Ordonez CP, Philips B, Pinzon PQ, Fleming LM, Motiwala SR, Sriwattanakomen R, Ho JE, Grandin EW, Sabe M, Garan AR. Cardiogenic shock related cardiovascular disease mortality trends in US population: Heart failure vs. acute myocardial infarction as contributing causes. Volume 367. International journal of cardiology 2022. PMID: 36002041


  6. Salia S, Mostofsky E, Gupta S, Lehman L, Barrera FJ, Liou L, Motiwala SR, Mittleman MA. Post-transplant mortality and graft failure after induction immunosuppression among Black heart transplant recipients in the United States. Volume 22 of Issue 11. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2022. PMID: 35758522


  7. Writing Committee, Maddox TM, Januzzi JL, Allen LA, Breathett K, Butler J, Davis LL, Fonarow GC, Ibrahim NE, Lindenfeld J, Masoudi FA, Motiwala SR, Oliveros E, Patterson JH, Walsh MN, Wasserman A, Yancy CW, Youmans QR. 2021 Update to the 2017 ACC Expert Consensus Decision Pathway for Optimization of Heart Failure Treatment: Answers to 10 Pivotal Issues About Heart Failure With Reduced Ejection Fraction: A Report of the American College of Cardiology Solution Set Oversig Volume 77 of Issue 6. Journal of the American College of Cardiology 2021. PMID: 33446410


  8. Motiwala SR. From Proteomics to Therapeutics: Sex Differences in Cardiovascular Disease Risk Do Matter. Volume 74 of Issue 12. Journal of the American College of Cardiology 2019. PMID: 31537264


  9. McCarthy CP, Ibrahim NE, van Kimmenade RRJ, Gaggin HK, Simon ML, Gandhi P, Kelly N, Motiwala SR, Mukai R, Magaret CA, Barnes G, Rhyne RF, Garasic JM, Januzzi JL. A clinical and proteomics approach to predict the presence of obstructive peripheral arterial disease: From the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) Study. Volume 41 of Issue 7. Clinical cardiology 2018. PMID: 29876944


  10. McCarthy CP, Ibrahim NE, Lyass A, Li Y, Gaggin HK, Simon ML, Mukai R, Gandhi P, Kelly N, Motiwala SR, van Kimmenade RRJ, Massaro JM, D'Agostino RB, Januzzi JL. Single-Molecule Counting of High-Sensitivity Troponin I in Patients Referred for Diagnostic Angiography: Results From the CASABLANCA (Catheter Sampled Blood Archive in Cardiovascular Diseases) Study. Volume 7 of Issue 6. Journal of the American Heart Association 2018. PMID: 29519811


  11. Ibrahim NE, Lyass A, Gaggin HK, Liu Y, van Kimmenade RRJ, Motiwala SR, Kelly NP, Gandhi PU, Simon ML, Belcher AM, Harisiades JE, Massaro JM, D'Agostino RB, Januzzi JL. Predicting new-onset HF in patients undergoing coronary or peripheral angiography: results from the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) study. Volume 5 of Issue 3. ESC heart failure 2018. PMID: 29424480


  12. Yancy CW, Januzzi JL, Allen LA, Butler J, Davis LL, Fonarow GC, Ibrahim NE, Jessup M, Lindenfeld J, Maddox TM, Masoudi FA, Motiwala SR, Patterson JH, Walsh MN, Wasserman A. 2017 ACC Expert Consensus Decision Pathway for Optimization of Heart Failure Treatment: Answers to 10 Pivotal Issues About Heart Failure With Reduced Ejection Fraction: A Report of the American College of Cardiology Task Force on Expert Consensus Decisi Volume 71 of Issue 2. Journal of the American College of Cardiology 2017. PMID: 29277252


  13. Gaggin HK, Truong QA, Gandhi PU, Motiwala SR, Belcher AM, Weiner RB, Baggish AL, Januzzi JL. Systematic Evaluation of Endothelin 1 Measurement Relative to Traditional and Modern Biomarkers for Clinical Assessment and Prognosis in Patients With Chronic Systolic Heart Failure: Serial Measurement and Multimarker Testing. Volume 147 of Issue 5. American journal of clinical pathology 2017. PMID: 28398455


  14. McCarthy CP, van Kimmenade RRJ, Gaggin HK, Simon ML, Ibrahim NE, Gandhi P, Kelly N, Motiwala SR, Belcher AM, Harisiades J, Magaret CA, Rhyne RF, Januzzi JL. Usefulness of Multiple Biomarkers for Predicting Incident Major Adverse Cardiac Events in Patients Who Underwent Diagnostic Coronary Angiography (from the Catheter Sampled Blood Archive in Cardiovascular Diseases [CASABLANCA] Study). Volume 120 of Issue 1. The American journal of cardiology 2017. PMID: 28487034


  15. Celano CM, Beale EE, Beach SR, Belcher AM, Suarez L, Motiwala SR, Gandhi PU, Gaggin H, Januzzi JL, Healy BC, Huffman JC. Associations Between Psychological Constructs and Cardiac Biomarkers After Acute Coronary Syndrome. Volume 79 of Issue 3. Psychosomatic medicine 2017. PMID: 27749683


  16. Ibrahim NE, Januzzi JL, Magaret CA, Gaggin HK, Rhyne RF, Gandhi PU, Kelly N, Simon ML, Motiwala SR, Belcher AM, van Kimmenade RRJ. A Clinical and Biomarker Scoring System to Predict the Presence of Obstructive Coronary Artery Disease. Volume 69 of Issue 9. Journal of the American College of Cardiology 2017. PMID: 28254177


  17. Nakamori S, Alakbarli J, Bellm S, Motiwala SR, Addae G, Manning WJ, Nezafat R. Native T1 value in the remote myocardium is independently associated with left ventricular dysfunction in patients with prior myocardial infarction. Volume 46 of Issue 4. Journal of magnetic resonance imaging : JMRI 2017. PMID: 28152237


  18. Gaggin HK, Liu Y, Lyass A, van Kimmenade RR, Motiwala SR, Kelly NP, Mallick A, Gandhi PU, Ibrahim NE, Simon ML, Bhardwaj A, Belcher AM, Harisiades JE, Massaro JM, D'Agostino RB, Januzzi JL. Incident Type 2 Myocardial Infarction in a Cohort of Patients Undergoing Coronary or Peripheral Arterial Angiography. Volume 135 of Issue 2. Circulation 2016. PMID: 27881568


  19. Motiwala SR, Gaggin HK. Biomarkers to Predict Reverse Remodeling and Myocardial Recovery in Heart Failure. Volume 13 of Issue 5. Current heart failure reports 2016. PMID: 27726056


  20. Huffman JC, Beale EE, Celano CM, Beach SR, Belcher AM, Moore SV, Suarez L, Motiwala SR, Gandhi PU, Gaggin HK, Januzzi JL. Effects of Optimism and Gratitude on Physical Activity, Biomarkers, and Readmissions After an Acute Coronary Syndrome: The Gratitude Research in Acute Coronary Events Study. Volume 9 of Issue 1. Circulation. Cardiovascular quality and outcomes 2015. PMID: 26646818


  21. Huffman JC, Beale EE, Beach SR, Celano CM, Belcher AM, Moore SV, Suarez L, Gandhi PU, Motiwala SR, Gaggin H, Januzzi JL. Design and baseline data from the Gratitude Research in Acute Coronary Events (GRACE) study. Volume 44. Contemporary clinical trials 2015. PMID: 26166171


  22. Motiwala SR, Delling FN. Assessment of mitral valve disease: a review of imaging modalities. Current treatment options in cardiovascular medicine 2015. PMID: 25981195


  23. Motiwala SR, Gaggin HK, Gandhi PU, Belcher A, Weiner RB, Baggish AL, Szymonifka J, Januzzi JL. Concentrations of highly sensitive cardiac troponin-I predict poor cardiovascular outcomes and adverse remodeling in chronic heart failure. Volume 8 of Issue 3. Journal of cardiovascular translational research 2015. PMID: 25777344


  24. De Berardinis B, Gaggin HK, Magrini L, Belcher A, Zancla B, Femia A, Simon M, Motiwala S, Bhardwaj A, Parry BA, Nagurney JT, Coudriou C, Legrand M, Sadoune M, Di Somma S, Januzzi JL, Global Research on Acute Conditions Team (GREAT). Comparison between admission natriuretic peptides, NGAL and sST2 testing for the prediction of worsening renal function in patients with acutely decompensated heart failure. Volume 53 of Issue 4. Clinical chemistry and laboratory medicine 2015. PMID: 25473804


  25. Gandhi PU, Motiwala SR, Belcher AM, Gaggin HK, Weiner RB, Baggish AL, Fiuzat M, Brunner-La Rocca HP, Januzzi JL. Galectin-3 and mineralocorticoid receptor antagonist use in patients with chronic heart failure due to left ventricular systolic dysfunction. Volume 169 of Issue 3. American heart journal 2015. PMID: 25728731


  26. Legrand M, De Berardinis B, Gaggin HK, Magrini L, Belcher A, Zancla B, Femia A, Simon M, Motiwala S, Sambhare R, Di Somma S, Mebazaa A, Vaidya VS, Januzzi JL, Global Research on Acute Conditions Team (GREAT). Evidence of uncoupling between renal dysfunction and injury in cardiorenal syndrome: insights from the BIONICS study. Volume 9 of Issue 11. PloS one 2014. PMID: 25386851


  27. Bayes-Genis A, Januzzi JL, Gaggin HK, de Antonio M, Motiwala SR, Zamora E, Galán A, Domingo M, Urrutia A, Lupón J. ST2 pathogenetic profile in ambulatory heart failure patients. Volume 21 of Issue 4. Journal of cardiac failure 2014. PMID: 25451702


  29. Gandhi PU, Gaggin HK, Sheftel AD, Belcher AM, Weiner RB, Baggish AL, Motiwala SR, Liu PP, Januzzi JL. Prognostic usefulness of insulin-like growth factor-binding protein 7 in heart failure with reduced ejection fraction: a novel biomarker of myocardial diastolic function? Volume 114 of Issue 10. The American journal of cardiology 2014. PMID: 25248814


  30. Gaggin HK, Szymonifka J, Bhardwaj A, Belcher A, De Berardinis B, Motiwala S, Wang TJ, Januzzi JL. Head-to-head comparison of serial soluble ST2, growth differentiation factor-15, and highly-sensitive troponin T measurements in patients with chronic heart failure. Volume 2 of Issue 1. JACC. Heart failure 2014. PMID: 24622120


  31. Motiwala SR, Szymonifka J, Belcher A, Weiner RB, Baggish AL, Gaggin HK, Bhardwaj A, Januzzi JL. Measurement of novel biomarkers to predict chronic heart failure outcomes and left ventricular remodeling. Volume 7 of Issue 2. Journal of cardiovascular translational research 2013. PMID: 24309956


  32. Motiwala SR, Sarma A, Januzzi JL, O'Donoghue ML. Biomarkers in ACS and heart failure: should men and women be interpreted differently? Volume 60 of Issue 1. Clinical chemistry 2013. PMID: 24255075


  33. Gaggin HK, Motiwala S, Bhardwaj A, Parks KA, Januzzi JL. Soluble concentrations of the interleukin receptor family member ST2 and β-blocker therapy in chronic heart failure. Volume 6 of Issue 6. Circulation. Heart failure 2013. PMID: 24114865


  34. Motiwala SR, Szymonifka J, Belcher A, Weiner RB, Baggish AL, Sluss P, Gaggin HK, Bhardwaj A, Januzzi JL. Serial measurement of galectin-3 in patients with chronic heart failure: results from the ProBNP Outpatient Tailored Chronic Heart Failure Therapy (PROTECT) study. Volume 15 of Issue 10. European journal of heart failure 2013. PMID: 23666680


  35. Motiwala SR, Januzzi JL. Using biomarkers to "guide" heart failure management: current perspectives and future directions. Volume 21 of Issue 3. Cardiology in review 2013. PMID: 23032578


  36. Huffman JC, Celano CM, Beach SR, Motiwala SR, Januzzi JL. Depression and cardiac disease: epidemiology, mechanisms, and diagnosis. Volume 2013. Cardiovascular psychiatry and neurology 2013. PMID: 23653854


  37. Motiwala SR, Januzzi JL. The role of natriuretic peptides as biomarkers for guiding the management of chronic heart failure. Volume 93 of Issue 1. Clinical pharmacology and therapeutics 2012. PMID: 23187878


  38. Motiwala SR, Wang TJ. Vitamin D and cardiovascular risk. Volume 14 of Issue 3. Current hypertension reports 2012. PMID: 22457243


  39. Motiwala SR, Wang TJ. Vitamin D and cardiovascular disease. Volume 20 of Issue 4. Current opinion in nephrology and hypertension 2011. PMID: 21519252