Roselle Abraham, MD

Associate Professor

CLINICAL INTERESTS: Dr. Roselle Abraham is a cardiologist with expertise in the treatment of patients with hypertrophic cardiomyopathy.

RESEARCH INTERESTS: Dr. Roselle Abraham is a physician scientist with a background in electrophysiology, imaging and stem cell research. She is using multi-modality imaging for risk stratification of atrial and ventricular arrhythmias. The overall goal of her research program is to use a combination of multi-modality clinical imaging and studies in model systems to tailor therapies for patients with hypertrophic cardiomyopathy.
Publications
  1. Huang Y, Lu H, Ren X, Li F, Bu W, Liu W, Dailey WP, Saeki H, Gabrielson K, Abraham R, Eckenhoff R, Gao WD. Fropofol prevents disease progression in mice with hypertrophic cardiomyopathy. 2020. PMID: 31424496


  2. Yalcin H, Valenta I, Zhao M, Tahari A, Lu DY, Higuchi T, Yalcin F, Kucukler N, Soleimanifard Y, Zhou Y, Pomper MG, Abraham TP, Tsui B, Lodge MA, Schindler TH, Abraham MR. Correction to: Comparison of two software systems for quantification of myocardial blood flow in patients with hypertrophic cardiomyopathy. 2018. PMID: 29423907


  3. Vakrou S, Fukunaga R, Foster DB, Sorensen L, Liu Y, Guan Y, Woldemichael K, Pineda-Reyes R, Liu T, Tardiff JC, Leinwand LA, Tocchetti CG, Abraham TP, O'Rourke B, Aon MA, Abraham MR. Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models. 2018. PMID: 29563334


  4. Lu DY, Pozios I, Haileselassie B, Ventoulis I, Liu H, Sorensen LL, Canepa M, Phillip S, Abraham MR, Abraham TP. Clinical Outcomes in Patients With Nonobstructive, Labile, and Obstructive Hypertrophic Cardiomyopathy. 2018. PMID: 29478967


  5. Pozios I, Pinheiro A, Corona-Villalobos C, Sorensen LL, Dardari Z, Liu HY, Cresswell K, Phillip S, Bluemke DA, Zimmerman SL, Abraham MR, Abraham TP. Rest and Stress Longitudinal Systolic Left Ventricular Mechanics in Hypertrophic Cardiomyopathy: Implications for Prognostication. 2018. PMID: 29426649


  6. Lu DY, Yalçin H, Yalçin F, Zhao M, Sivalokanathan S, Valenta I, Tahari A, Pomper MG, Abraham TP, Schindler TH, Abraham MR. Stress Myocardial Blood Flow Heterogeneity Is a Positron Emission Tomography Biomarker of Ventricular Arrhythmias in Patients With Hypertrophic Cardiomyopathy. 2018. PMID: 29678336


  7. Yalcin H, Valenta I, Zhao M, Tahari A, Lu DY, Higuchi T, Yalcin F, Kucukler N, Soleimanifard Y, Zhou Y, Pomper MG, Abraham TP, Tsui B, Lodge MA, Schindler TH, Roselle Abraham M. Comparison of two software systems for quantification of myocardial blood flow in patients with hypertrophic cardiomyopathy. 2018. PMID: 29359273


  8. Lu DY, Haileselassie B, Ventoulis I, Liu HY, Liang HY, Pozios I, Canepa M, Phillip S, Abraham MR, Abraham T. E/e' ratio and outcome prediction in hypertrophic cardiomyopathy: the influence of outflow tract obstruction. 2018. PMID: 28977350


  9. Lu DY, Hailesealassie B, Ventoulis I, Liu H, Liang HY, Nowbar A, Pozios I, Canepa M, Cresswell K, Luo HC, Abraham MR, Abraham TP. Impact of peak provoked left ventricular outflow tract gradients on clinical outcomes in hypertrophic cardiomyopathy. 2017. PMID: 28747034


  10. Chu LC, Corona-Villalobos CP, Halushka MK, Zhang Y, Pozzessere C, Kamel IR, Pozios I, Van Der Geest RJ, Gai N, Abraham RM, Abraham TP, Bluemke DA, Zimmerman SL. Structural and Functional Correlates of Myocardial T1 Mapping in 321 Patients With Hypertrophic Cardiomyopathy. 2017. PMID: 27997439


  11. Liu H, Pozios I, Haileselassie B, Nowbar A, Sorensen LL, Phillip S, Lu DY, Ventoulis I, Luo H, Abraham MR, Abraham TP. Role of Global Longitudinal Strain in Predicting Outcomes in Hypertrophic Cardiomyopathy. 2017. PMID: 28687124


  12. Corona-Villalobos CP, Saha S, Pozios I, Hurtado-de-Mendoza Paz D, Sorensen L, Gonzalez Cordoba J, Dolores-Cerna K, Kamel IR, Mormontoy Laurel W, Bluemke DA, Abraham TP, Zimmerman SL, Abraham MR. Exercise-QTc is associated with diffuse interstitial fibrosis reflected by lower approximated T1 relaxation time in hypertrophic cardiomyopathy patients. 2017. PMID: 28292523


  13. Hurtado-de-Mendoza D, Corona-Villalobos CP, Pozios I, Gonzales J, Soleimanifard Y, Sivalokanathan S, Montoya-Cerrillo D, Vakrou S, Kamel I, Mormontoy-Laurel W, Dolores-Cerna K, Suarez J, Perez-Melo S, Bluemke DA, Abraham TP, Zimmerman SL, Abraham MR. Diffuse interstitial fibrosis assessed by cardiac magnetic resonance is associated with dispersion of ventricular repolarization in patients with hypertrophic cardiomyopathy. 2016. PMID: 28607615


  14. Sorensen LL, Liang HY, Pinheiro A, Hilser A, Dimaano V, Olsen NT, Hansen TF, Sogaard P, Nowbar A, Pisanello C, Pozios I, Phillip S, Zhou X, Abraham R, Abraham TP. Safety profile and utility of treadmill exercise in patients with high-gradient hypertrophic cardiomyopathy. 2016. PMID: 27892886


  15. Yalçin H, Valenta I, Yalçin F, Corona-Villalobos C, Vasquez N, Ra J, Kucukler N, Tahari A, Pozios I, Zhou Y, Pomper M, Abraham TP, Schindler TH, Abraham MR. Effect of Diffuse Subendocardial Hypoperfusion on Left Ventricular Cavity Size by 13N-Ammonia Perfusion PET in Patients With Hypertrophic Cardiomyopathy. 2016. PMID: 27771003


  16. Lin X, Steinberg S, Kandasamy SK, Afzal J, Mbiyangandu B, Liao SE, Guan Y, Corona-Villalobos CP, Matkovich SJ, Epstein N, Tripodi D, Huo Z, Cutting G, Abraham TP, Fukunaga R, Abraham MR. Common miR-590 Variant rs6971711 Present Only in African Americans Reduces miR-590 Biogenesis. 2016. PMID: 27196440


  17. Sørensen LL, Bedja D, Sysa-Shah P, Liu H, Maxwell A, Yi X, Pozios I, Olsen NT, Abraham TP, Abraham R, Gabrielson K. Echocardiographic Characterization of a Murine Model of Hypertrophic Obstructive Cardiomyopathy Induced by Cardiac-specific Overexpression of Epidermal Growth Factor Receptor 2. 2016. PMID: 27538857


  18. Ardekani S, Jain S, Sanzi A, Corona-Villalobos CP, Abraham TP, Abraham MR, Zimmerman SL, Wu KC, Winslow RL, Miller MI, Younes L. Shape analysis of hypertrophic and hypertensive heart disease using MRI-based 3D surface models of left ventricular geometry. 2015. PMID: 26766206


  19. Pozios I, Corona-Villalobos C, Sorensen LL, Bravo PE, Canepa M, Pisanello C, Pinheiro A, Dimaano VL, Luo H, Dardari Z, Zhou X, Kamel I, Zimmerman SL, Bluemke DA, Abraham MR, Abraham TP. Comparison of Outcomes in Patients With Nonobstructive, Labile-Obstructive, and Chronically Obstructive Hypertrophic Cardiomyopathy. 2015. PMID: 26239580


  20. Bravo PE, Luo HC, Pozios I, Zimmerman SL, Corona-Villalobos CP, Sorensen L, Kamel IR, Bluemke DA, Wahl RL, Abraham MR, Abraham TP. Late gadolinium enhancement confined to the right ventricular insertion points in hypertrophic cardiomyopathy: an intermediate stage phenotype? 2015. PMID: 26077330


  21. Bravo PE, Tahari A, Pozios I, Luo HC, Bengel FM, Wahl RL, Abraham MR, Abraham TP. Apparent left ventricular cavity dilatation during PET/CT in hypertrophic cardiomyopathy: Clinical predictors and potential mechanisms. 2015. PMID: 25989730


  22. Rahman QA, Tereshchenko LG, Kongkatong M, Abraham T, Abraham MR, Shatkay H. Utilizing ECG-Based Heartbeat Classification for Hypertrophic Cardiomyopathy Identification. 2015. PMID: 25915962


  23. Luo HC, Dimaano VL, Kembro JM, Hilser A, Hurtado-de-Mendoza D, Pozios I, Tomas MS, Yalcin H, Dolores-Cerna K, Mormontoy W, Aon MA, Cameron D, Bluemke DA, Stewart KJ, Russell SD, Cordova JG, Abraham TP, Abraham MR. Exercise heart rates in patients with hypertrophic cardiomyopathy. 2015. PMID: 25746289


  24. Rahman QA, Tereshchenko LG, Kongkatong M, Abraham T, Abraham MR, Shatkay H. Identifying Hypertrophic Cardiomyopathy Patients by Classifying Individual Heartbeats from 12-lead ECG Signals. 2014. PMID: 25737801


  25. Luo HC, Pozios I, Vakrou S, Sorensen L, Abraham RM, Abraham T. Age-related changes in familial hypertrophic cardiomyopathy phenotype in transgenic mice and humans. 2014. PMID: 25318870


  26. Vakrou S, Abraham MR. Hypertrophic cardiomyopathy: a heart in need of an energy bar? 2014. PMID: 25191275


  27. Canepa M, Sorensen LL, Pozios I, Dimaano VL, Luo HC, Pinheiro AC, Strait JB, Brunelli C, Abraham MR, Ferrucci L, Abraham TP. Comparison of clinical presentation, left ventricular morphology, hemodynamics, and exercise tolerance in obese versus nonobese patients with hypertrophic cardiomyopathy. 2013. PMID: 24079444


  28. Lin X, Liang HY, Pinheiro A, Dimaano V, Sorensen L, Aon M, Tereshchenko LG, Chen Y, Xiang M, Abraham TP, Abraham MR. Electromechanical relationship in hypertrophic cardiomyopathy. 2013. PMID: 23771430


  29. Abraham MR, Bottomley PA, Dimaano VL, Pinheiro A, Steinberg A, Traill TA, Abraham TP, Weiss RG. Creatine kinase adenosine triphosphate and phosphocreatine energy supply in a single kindred of patients with hypertrophic cardiomyopathy. 2013. PMID: 23751935


  30. Rischpler C, Fukushima K, Isoda T, Javadi MS, Dannals RF, Abraham R, Wahl R, Bengel FM, Higuchi T. Discrepant uptake of the radiolabeled norepinephrine analogues hydroxyephedrine (HED) and metaiodobenzylguanidine (MIBG) in rat hearts. 2013. PMID: 23539177


  31. Bravo PE, Zimmerman SL, Luo HC, Pozios I, Rajaram M, Pinheiro A, Steenbergen C, Kamel IR, Wahl RL, Bluemke DA, Bengel FM, Abraham MR, Abraham TP. Relationship of delayed enhancement by magnetic resonance to myocardial perfusion by positron emission tomography in hypertrophic cardiomyopathy. 2013. PMID: 23418294


  32. Hueper K, Zapf A, Skrok J, Pinheiro A, Goldstein TA, Zheng J, Zimmerman SL, Kamel IR, Abraham R, Wacker F, Bluemke DA, Abraham T, Vogel-Claussen J. In hypertrophic cardiomyopathy reduction of relative resting myocardial blood flow is related to late enhancement, T2-signal and LV wall thickness. 2012. PMID: 22860042


  33. Vogel-Claussen J, Santaularia Tomas M, Newatia A, Boyce D, Pinheiro A, Abraham R, Abraham T, Bluemke DA. Cardiac MRI evaluation of hypertrophic cardiomyopathy: left ventricular outflow tract/aortic valve diameter ratio predicts severity of LVOT obstruction. 2012. PMID: 22549972


  34. Bravo PE, Pinheiro A, Higuchi T, Rischpler C, Merrill J, Santaularia-Tomas M, Abraham MR, Wahl RL, Abraham TP, Bengel FM. PET/CT assessment of symptomatic individuals with obstructive and nonobstructive hypertrophic cardiomyopathy. 2012. PMID: 22315440