Mandar Aras, MD, PhD

Associate Professor

I am an advanced heart failure and heart transplant cardiologist who has expertise in the management of patients with heart failure and pulmonary hypertension, heart transplant, and mechanical circulatory support devices. I am co-Director of the UCSF Comprehensive Amyloidosis Program, and the clinical cardiology lead for the UCSF HHT Center of Excellence. In addition to my expertise in heart failure and cardiomyopathies, I developed a specific focus in cardio-oncology (management of cardiovascular issues in cancer patients).

My research interests focus on understanding infiltrative and inflammatory heart diseases.

Education
2020 - Diversity, Equity, and Inclusion Champion Training, University of California
Fellowship, 2018 - Advanced Heart Failure/Transplant, University of California
Fellowship, 2017 - Cardiovascular disease, University of California
Residency, 2014 - Internal Medicine, Duke University Medical Center
MD, PhD, 2011 - Medicine, Neurobiology, University of Pittsburgh
Honors and Awards
  • ACC Clinical Excellence in Cardiology Fellowship Award, UCSF, 2016
  • Califf Medicine Resident Research Award, Duke, 2014
  • International Society for Zinc Biology Best Poster Award, 2009
  • International Society for Zinc Biology Best Student Oral Presentation, 2008
  • Summa Cum Laude with Honors, University of Pittsburgh, 2004
Publications

  1. Yurk D, Barrios JP, Labrecque Langlais E, Avram R, Aras MA, Abu-Mostafa Y, Padmanabhan A, Tison GH. Automated Assessment of Right Atrial Pressure From Ultrasound Videos Using Machine Learning. JACC. Advances 2024. PMID: 39372459


  2. Lassen MCH, Arya F, Biering-Sørensen T, Reeh JLT, Melisko ME, Sarwary S, Baik AH, Aras MA, Qasim A. Left atrial strain is reduced following trastuzumab in breast cancer patients. Echocardiography (Mount Kisco, N.Y.) 2024. PMID: 38284677


  3. Ahmad Masri, Mandar Aras, Rodney H. Falk, Martha Grogan, Daniel Jacoby, Mathew S. Maurer, Sanjiv J. Shah, Ronald Witteles, Paul W. Wong, Alan X. Ji, Jing Du, Suresh Siddhanti, Uma Sinha, Jonathan C. Fox, Daniel P. Judge. Long-term Safety And Tolerability Of Acoramidis (AG10) In Symptomatic Transthyretin Amyloid Cardiomyopathy: 4-year Update From An Ongoing, Phase 2, Open-label Extension Study. Journal of cardiac failure 2024. PMID:


  4. Stern LK, Grodin JL, Maurer MS, Ruberg FL, Patel AR, Khouri MG, Roth LR, Aras MA, Bhardwaj A, Bhattacharya P, Brailovsky Y, Drachman BM, Ebong IA, Fine NM, Gaggin H, Gopal D, Griffin J, Judge D, Kim P, Mitchell J, Mitter SS, Mohan RC, Ramos H, Reyentovich A, Sheikh FH, Sperry B, Carter S, Urey M, Vaishnav J, Vest AR, Kittleson MM, Patel JK. The Cardiac Amyloidosis Registry Study (CARS): Rationale, Design and Methodology. Journal of cardiac failure 2023. PMID: 37907148


  5. Durstenfeld MS, Peluso MJ, Spinelli MA, Li D, Hoh R, Chenna A, Yee B, Winslow J, Petropoulos C, Gandhi M, Henrich TJ, Aras MA, Long CS, Deeks SG, Hsue PY. Association of SARS-CoV-2 Infection and Cardiopulmonary Long COVID With Exercise Capacity and Chronotropic Incompetence Among People With HIV. Journal of the American Heart Association 2023. PMID: 37830367


  6. Durstenfeld MS, Peluso MJ, Kaveti P, Hill C, Li D, Sander E, Swaminathan S, Arechiga VM, Lu S, Goldberg SA, Hoh R, Chenna A, Yee BC, Winslow JW, Petropoulos CJ, Kelly JD, Glidden DV, Henrich TJ, Martin JN, Lee YJ, Aras MA, Long CS, Grandis DJ, Deeks SG, Hsue PY. Reduced exercise capacity, chronotropic incompetence, and early systemic inflammation in cardiopulmonary phenotype Long COVID. The Journal of infectious diseases 2023. PMID: 37166076


  7. Durstenfeld MS, Peluso MJ, Spinelli MA, Li D, Hoh R, Gandhi M, Henrich TJ, Aras MA, Long CS, Deeks SG, Hsue PY. Association of SARS-CoV-2 Infection and Cardiopulmonary Long COVID with Exercise Capacity and Chronotropic Incompetence among People with HIV. medRxiv : the preprint server for health sciences 2023. PMID: 37205522


  8. Durstenfeld MS, Peluso MJ, Kaveti P, Hill C, Li D, Sander E, Swaminathan S, Arechiga VM, Sun K, Ma Y, Zepeda V, Lu S, Goldberg SA, Hoh R, Chenna A, Yee BC, Winslow JW, Petropoulos CJ, Win S, Kelly JD, Glidden DV, Henrich TJ, Martin JN, Lee YJ, Aras MA, Long CS, Grandis DJ, Deeks SG, Hsue PY. Inflammation during early post-acute COVID-19 is associated with reduced exercise capacity and Long COVID symptoms after 1 year. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35677073


  9. Kennedy VE, Natsuhara K, Shah ND, Arora S, Wolf J, Martin TG, Aras MA, Chung A, Wong SW. Daratumumab Plus Bortezomib and Dexamethasone in Newly Diagnosed Systemic Light Chain Amyloidosis. Current problems in cancer 2023. PMID: 36807996


  10. Aras MA, Abreau S, Mills H, Radhakrishnan L, Klein L, Mantri N, Rubin B, Barrios J, Chehoud C, Kogan E, Gitton X, Nnewihe A, Quinn D, Bridges C, Butte AJ, Olgin JE, Tison GH. Electrocardiogram Detection of Pulmonary Hypertension Using Deep Learning. Journal of cardiac failure 2023. PMID: 36706977


  12. Benza RL, Franco V, Aras MA, Spikes L, Grinnan D, Satler C. Safety and efficacy of RT234 vardenafil inhalation powder on exercise parameters in pulmonary arterial hypertension: phase II, dose-escalation study design. Respiratory research 2022. PMID: 36527025


  13. Durstenfeld MS, Sun K, Tahir P, Peluso MJ, Deeks SG, Aras MA, Grandis DJ, Long CS, Beatty A, Hsue PY. Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults: A Systematic Review and Meta-analysis. JAMA network open 2022. PMID: 36223120


  14. Nowatzke J, Guedeney P, Palaskas N, Lehmann L, Ederhy S, Zhu H, Cautela J, Francis S, Courand PY, Deswal A, Ewer SM, Aras M, Arangalage D, Ghafourian K, Fenioux C, Finke D, Peretto G, Zaha V, Itzhaki Ben Zadok O, Tajiri K, Akhter N, Levenson J, Baldassarre L, Power J, Huang S, Collet JP, Moslehi J, Salem JE, International ICI-myocarditis registry contributors. Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry. European journal of cancer (Oxford, England : 1990) 2022. PMID: 36030143


  15. Durstenfeld MS, Sun K, Tahir PM, Peluso MJ, Deeks SG, Aras MA, Grandis DJ, Long CS, Beatty A, Hsue PY. Cardiopulmonary exercise testing to evaluate post-acute sequelae of COVID-19 ("Long COVID"): a systematic review and meta-analysis. medRxiv : the preprint server for health sciences 2022. PMID: 35734081


  16. Power JR, Alexandre J, Choudhary A, Ozbay B, Hayek SS, Asnani A, Tamura Y, Aras M, Cautela J, Thuny F, Gilstrap L, Arangalage D, Ewer S, Huang S, Deswal A, Palaskas NL, Finke D, Lehmann LH, Ederhy S, Moslehi J, Salem JE, International ICI-Myocarditis Registry. Association of early electrical changes with cardiovascular outcomes in immune checkpoint inhibitor myocarditis. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35595646


  17. Banerjee R, Lo M, Klein L, Aras M, Logan AC. Anthracyclines in a patient with acute leukemia and severe cardiomyopathy requiring mechanical support: A case report. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34846217


  18. Lehmann LH, Cautela J, Palaskas N, Baik AH, Meijers WC, Allenbach Y, Alexandre J, Rassaf T, Müller OJ, Aras M, Asnani AH, Deswal A, Laufer-Perl M, Thuny F, Kerneis M, Hayek SS, Ederhy S, Salem JE, Moslehi JJ. Clinical Strategy for the Diagnosis and Treatment of Immune Checkpoint Inhibitor-Associated Myocarditis: A Narrative Review. JAMA cardiology 2021. PMID: 34232253


  19. Power JR, Alexandre J, Choudhary A, Ozbay B, Hayek S, Asnani A, Tamura Y, Aras M, Cautela J, Thuny F, Gilstrap L, Arangalage D, Ewer S, Huang S, Deswal A, Palaskas NL, Finke D, Lehman L, Ederhy S, Moslehi J, Salem JE, International ICI-Myocarditis Registry†. Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34723640


  20. Gabriela Spencer-Bonilla, Joyce N. Njoroge, Keon Pearson, Ronald M. Witteles, Mandar A. Aras, Kevin M. Alexander. Racial and Ethnic Disparities in Transthyretin Cardiac Amyloidosis. Current Cardiovascular Risk Reports 2021. PMID:


  21. Spencer-Bonilla G, Njoroge JN, Pearson K, Witteles RM, Aras MA, Alexander KM. Racial and Ethnic Disparities in Transthyretin Cardiac Amyloidosis. Current Cardiovascular Risk Reports 2021. PMID: 35280930


  22. Baik AH, Tsai KK, Oh DY, Aras MA. Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors. Clinical science (London, England : 1979) 2021. PMID: 33686402


  23. J Power, W Meijers, C Fenioux, Y Tamura, A Asnani, J Alexandre, J Cautela, M Aras, L Lehmann, M Perl, A Narezkina, L Gilstrap, S Ederhy, J Moslehi, J Salem. Predictors of steroid-refractory immune checkpoint inhibitor associated myocarditis. European heart journal 2020. PMID:


  25. Hasan Shandhi MM, Aras M, Wynn S, Fan J, Heller JA, Etemadi M, Klein L, Inan OT. Cardiac Function Monitoring for Patients Undergoing Cancer Treatments Using Wearable Seismocardiography: A Proof-of-Concept Study. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2020. PMID: 33018894


  26. Abraham TP, Aras MA. Echo-Strain to Check Up on Checkpoint Inhibitors. Journal of the American College of Cardiology 2020. PMID: 32029129


  27. Stern LK, Selby VN, Kolaitis NA, Boin F, Aras M, Klein L, De Marco T. Heart-lung transplantation: A viable option for connective tissue diseases. Clinical transplantation 2019. PMID: 31867763


  28. DesJardin JT, Manicardi M, Svetlichnaya Y, Kolaitis NA, Papolos AI, Selby VN, Zier LS, Klein L, Aras MA, Yao FY, Roberts JP, De Marco T. Non-Invasive Estimation of Pulmonary Vascular Resistance Improves Portopulmonary Hypertension Screening in Liver Transplant Candidates. Clinical transplantation 2019. PMID: 31074522


  29. Aras MA, Psotka MA, De Marco T. Pulmonary Hypertension Due to Left Heart Disease: an Update. Current cardiology reports 2019. PMID: 31134443


  30. Zhang J, Gajjala S, Agrawal P, Tison GH, Hallock LA, Beussink-Nelson L, Lassen MH, Fan E, Aras MA, Jordan C, Fleischmann KE, Melisko M, Qasim A, Shah SJ, Bajcsy R, Deo RC. Fully Automated Echocardiogram Interpretation in Clinical Practice. Circulation 2018. PMID: 30354459


  31. Aras MA, Teerlink JR. Lung ultrasound: a 'B-line' to the prediction of decompensated heart failure. European heart journal 2016. PMID: 27080198


  32. Aras MA, Aizenman E. Redox regulation of intracellular zinc: molecular signaling in the life and death of neurons. Antioxidants & redox signaling 2011. PMID: 20849376


  33. Aras MA, Saadi RA, Aizenman E. Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia. The European journal of neuroscience 2009. PMID: 20092568


  34. Redman PT, Hartnett KA, Aras MA, Levitan ES, Aizenman E. Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling. The Journal of physiology 2009. PMID: 19622611


  35. Hershfinkel M, Kandler K, Knoch ME, Dagan-Rabin M, Aras MA, Abramovitch-Dahan C, Sekler I, Aizenman E. Intracellular zinc inhibits KCC2 transporter activity. Nature neuroscience 2009. PMID: 19430470


  36. Aras MA, Hara H, Hartnett KA, Kandler K, Aizenman E. Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning. Journal of neurochemistry 2009. PMID: 19453299


  37. Aras MA, Hartnett KA, Aizenman E. Assessment of cell viability in primary neuronal cultures. Current protocols in neuroscience 2008. PMID: 18633999


  38. Chalovich EM, Koike MA, Aras MA, Murphey-Corb M, Wiley CA, Jordan-Sciutto KL. Pocket proteins p107 and p130 exhibit increased expression in macrophages during SIV encephalitis. Neuropathology : official journal of the Japanese Society of Neuropathology 2005. PMID: 16382780


  39. Aras MA, Aizenman E. Obligatory role of ASK1 in the apoptotic surge of K+ currents. Neuroscience letters 2005. PMID: 16006035