Mandar Aras, MD, PhD
Assistant Professor
My research interests focus on cardiac amyloidosis and in understanding risk predictors and outcomes of cancer patients with heart disease.
Education
Honors and Awards
- ACC Clinical Excellence in Cardiology Fellowship Award, UCSF, 2016
- Califf Medicine Resident Research Award, Duke, 2014
- International Society for Zinc Biology Best Poster Award, 2009
- International Society for Zinc Biology Best Student Oral Presentation, 2008
- Summa Cum Laude with Honors, University of Pittsburgh, 2004
Publications
Stern LK, Grodin JL, Maurer MS, Ruberg FL, Patel AR, Khouri MG, Roth LR, Aras MA, Bhardwaj A, Bhattacharya P, Brailovsky Y, Drachman BM, Ebong IA, Fine NM, Gaggin H, Gopal D, Griffin J, Judge D, Kim P, Mitchell J, Mitter SS, Mohan RC, Ramos H, Reyentovich A, Sheikh FH, Sperry B, Carter S, Urey M, Vaishnav J, Vest AR, Kittleson MM, Patel JK. The Cardiac Amyloidosis Registry Study (CARS): Rationale, Design and Methodology. Journal of cardiac failure 2023. PMID: 37907148
Durstenfeld MS, Peluso MJ, Spinelli MA, Li D, Hoh R, Chenna A, Yee B, Winslow J, Petropoulos C, Gandhi M, Henrich TJ, Aras MA, Long CS, Deeks SG, Hsue PY. Association of SARS-CoV-2 Infection and Cardiopulmonary Long COVID With Exercise Capacity and Chronotropic Incompetence Among People With HIV. Journal of the American Heart Association 2023. PMID: 37830367
Durstenfeld MS, Peluso MJ, Kaveti P, Hill C, Li D, Sander E, Swaminathan S, Arechiga VM, Lu S, Goldberg SA, Hoh R, Chenna A, Yee BC, Winslow JW, Petropoulos CJ, Kelly JD, Glidden DV, Henrich TJ, Martin JN, Lee YJ, Aras MA, Long CS, Grandis DJ, Deeks SG, Hsue PY. Reduced exercise capacity, chronotropic incompetence, and early systemic inflammation in cardiopulmonary phenotype Long COVID. The Journal of infectious diseases 2023. PMID: 37166076
Javid J. Moslehi, Mandar A. Aras, Vivian G. Oehler, James E. Thompson, James K. McCloskey, Michael C. Heinrich, Irene S. DeGutis, Susan Meredith Fish, Michael J. Mauro. Longitudinal, prospective cardiovascular and metabolic risk in treatment-naive patients with chronic myeloid leukemia in chronic phase (CML-CP) starting tyrosine kinase inhibitor (TKI) therapy in a real-world setting. Journal of Clinical Oncology 2023. PMID:
Durstenfeld MS, Peluso MJ, Spinelli MA, Li D, Hoh R, Gandhi M, Henrich TJ, Aras MA, Long CS, Deeks SG, Hsue PY. Association of SARS-CoV-2 Infection and Cardiopulmonary Long COVID with Exercise Capacity and Chronotropic Incompetence among People with HIV. medRxiv : the preprint server for health sciences 2023. PMID: 37205522
Durstenfeld MS, Peluso MJ, Kaveti P, Hill C, Li D, Sander E, Swaminathan S, Arechiga VM, Sun K, Ma Y, Zepeda V, Lu S, Goldberg SA, Hoh R, Chenna A, Yee BC, Winslow JW, Petropoulos CJ, Win S, Kelly JD, Glidden DV, Henrich TJ, Martin JN, Lee YJ, Aras MA, Long CS, Grandis DJ, Deeks SG, Hsue PY. Inflammation during early post-acute COVID-19 is associated with reduced exercise capacity and Long COVID symptoms after 1 year. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35677073
Albert K. Feeny, Joshua Barrios, Sean Abreau, Jeffrey E. Olgin, Mandar Aras, Geoffrey H. Tison. ASSOCIATION BETWEEN ECG-BASED DEEP LEARNING PREDICTION OF PULMONARY HYPERTENSION AND TRANSTHORACIC ECHOCARDIOGRAM ESTIMATION OF PULMONARY ARTERY SYSTOLIC PRESSURE. Journal of the American College of Cardiology 2023. PMID:
Kennedy VE, Natsuhara K, Shah ND, Arora S, Wolf J, Martin TG, Aras MA, Chung A, Wong SW. Daratumumab Plus Bortezomib and Dexamethasone in Newly Diagnosed Systemic Light Chain Amyloidosis. Current problems in cancer 2023. PMID: 36807996
Aras MA, Abreau S, Mills H, Radhakrishnan L, Klein L, Mantri N, Rubin B, Barrios J, Chehoud C, Kogan E, Gitton X, Nnewihe A, Quinn D, Bridges C, Butte AJ, Olgin JE, Tison GH. Electrocardiogram Detection of Pulmonary Hypertension Using Deep Learning. Journal of cardiac failure 2023. PMID: 36706977
Lai M, Aras MA, Park M. Post-transplant ejection fraction and renal failure in cardiac transplant recipients: An analysis of the OPTN database. Clinical transplantation 2022. PMID: 36504467
Benza RL, Franco V, Aras MA, Spikes L, Grinnan D, Satler C. Safety and efficacy of RT234 vardenafil inhalation powder on exercise parameters in pulmonary arterial hypertension: phase II, dose-escalation study design. Respiratory research 2022. PMID: 36527025
Matthew S Durstenfeld, Michael J Peluso, Punita Kaveti, Christopher Hill, Danny Li, Erica Sander, Shreya Swaminathan, Victor M Arechiga, Kaiwen Sun, Yifei Ma, victor zepeda, Scott Lu, Sarah A Goldberg, Rebecca Hoh, Ahmed Chenna, Brandon C Yee, JOhn W Winslow, christos J petropoulos, Sithu Win, JOHN D KELLY, David V Glidden, Timothy J Henrich, Jeffrey N Martin, Yoo Jin Lee, Mandar A Aras, Carlin S Long, Donald J Grandis, Steven G Deeks, Priscilla Y Hsue. Abstract 10570: Inflammation During Early Post-Acute Covid-19 is Associated With Reduced Exercise Capacity and Long Covid Symptoms After 1 Year. Circulation 2022. PMID:
Durstenfeld MS, Sun K, Tahir P, Peluso MJ, Deeks SG, Aras MA, Grandis DJ, Long CS, Beatty A, Hsue PY. Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults: A Systematic Review and Meta-analysis. JAMA network open 2022. PMID: 36223120
Nowatzke J, Guedeney P, Palaskas N, Lehmann L, Ederhy S, Zhu H, Cautela J, Francis S, Courand PY, Deswal A, Ewer SM, Aras M, Arangalage D, Ghafourian K, Fenioux C, Finke D, Peretto G, Zaha V, Itzhaki Ben Zadok O, Tajiri K, Akhter N, Levenson J, Baldassarre L, Power J, Huang S, Collet JP, Moslehi J, Salem JE, International ICI-myocarditis registry contributors. Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry. European journal of cancer (Oxford, England : 1990) 2022. PMID: 36030143
Durstenfeld MS, Sun K, Tahir PM, Peluso MJ, Deeks SG, Aras MA, Grandis DJ, Long CS, Beatty A, Hsue PY. Cardiopulmonary exercise testing to evaluate post-acute sequelae of COVID-19 ("Long COVID"): a systematic review and meta-analysis. medRxiv : the preprint server for health sciences 2022. PMID: 35734081
Power JR, Alexandre J, Choudhary A, Ozbay B, Hayek SS, Asnani A, Tamura Y, Aras M, Cautela J, Thuny F, Gilstrap L, Arangalage D, Ewer S, Huang S, Deswal A, Palaskas NL, Finke D, Lehmann LH, Ederhy S, Moslehi J, Salem JE, International ICI-Myocarditis Registry. Association of early electrical changes with cardiovascular outcomes in immune checkpoint inhibitor myocarditis. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35595646
Andrew Hughes, John Power, Olusola A. Orimoloye, Joseph F. Nowatzke, Yuichi Tamura, Mandar Aras, Aarti Asnani, Pierre-Yves Courand, Roberta Florido, Salim Hayek, Vlad Gabriel Zaha, Anita Deswal, Javid Moslehi, Nicolas L. Palaskas. CLINICAL SIGNIFICANCE OF PERICARDIAL EFFUSION IN PATIENTS HOSPITALIZED WITH IMMUNE CHECKPOINT INHIBITOR ASSOCIATED MYOCARDITIS. Journal of the American College of Cardiology 2022. PMID:
Ahmad Masri, Mandar Aras, Rodney H. Falk, Martha Grogan, Daniel Jacoby, Daniel P. Judge, Sanjiv Jayendra Shah, Ronald Witteles, Alan X. Ji, Paul W. Wong, Xiaofan Cao, Rebecca Vanlandingham, Leonid Katz, Uma Sinha, Jonathan C. Fox, Mathew S. Maurer. LONG-TERM SAFETY AND TOLERABILITY OF ACORAMIDIS (AG10) IN SYMPTOMATIC TRANSTHYRETIN AMYLOID CARDIOMYOPATHY: UPDATED ANALYSIS FROM AN ONGOING PHASE 2 OPEN-LABEL EXTENSION STUDY. Journal of the American College of Cardiology 2022. PMID:
Banerjee R, Lo M, Klein L, Aras M, Logan AC. Anthracyclines in a patient with acute leukemia and severe cardiomyopathy requiring mechanical support: A case report. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34846217
Lehmann LH, Cautela J, Palaskas N, Baik AH, Meijers WC, Allenbach Y, Alexandre J, Rassaf T, Müller OJ, Aras M, Asnani AH, Deswal A, Laufer-Perl M, Thuny F, Kerneis M, Hayek SS, Ederhy S, Salem JE, Moslehi JJ. Clinical Strategy for the Diagnosis and Treatment of Immune Checkpoint Inhibitor-Associated Myocarditis: A Narrative Review. JAMA cardiology 2021. PMID: 34232253
Power JR, Alexandre J, Choudhary A, Ozbay B, Hayek S, Asnani A, Tamura Y, Aras M, Cautela J, Thuny F, Gilstrap L, Arangalage D, Ewer S, Huang S, Deswal A, Palaskas NL, Finke D, Lehman L, Ederhy S, Moslehi J, Salem JE, International ICI-Myocarditis Registry†. Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34723640
Olusola Orimoloye, John R. Power, Joseph Nowatzke, Andrew M. Hughes, Lorenz Lehmann, Jennifer Cautela, Mandar Aras, Alison Weppler, Anna Narezkina, Giovanni Peretto, Michal Pela, Shanthini M. Crusz, Aarti Asnani, Joe-Elie Salem, Anita Deswal, Nicolas Palaskas, Javid Moslehi. ECHOCARDIOGRAPHIC FEATURES OF IMMUNE CHECKPOINT INHIBITOR ASSOCIATED MYOCARDITIS AND THEIR ASSOCIATION WITH ADVERSE OUTCOMES. Journal of the American College of Cardiology 2021. PMID:
Spencer-Bonilla G, Njoroge JN, Pearson K, Witteles RM, Aras MA, Alexander KM. Racial and Ethnic Disparities in Transthyretin Cardiac Amyloidosis. Current Cardiovascular Risk Reports 2021. PMID: 35280930
Baik AH, Tsai KK, Oh DY, Aras MA. Mechanisms and clinical manifestations of cardiovascular toxicities associated with immune checkpoint inhibitors. Clinical science (London, England : 1979) 2021. PMID: 33686402
J Power, W Meijers, C Fenioux, Y Tamura, A Asnani, J Alexandre, J Cautela, M Aras, L Lehmann, M Perl, A Narezkina, L Gilstrap, S Ederhy, J Moslehi, J Salem. Predictors of steroid-refractory immune checkpoint inhibitor associated myocarditis. European heart journal 2020. PMID:
Aras MA, Power JR, Moslehi JJ. Inflammatory Biomarkers to Detect Immune Checkpoint Inhibitor-Associated Cardiotoxicity in Lung Cancer Patients: Ready for Prime Time? JACC. CardioOncology 2020. PMID: 34396257
Abraham TP, Aras MA. Echo-Strain to Check Up on Checkpoint Inhibitors. Journal of the American College of Cardiology 2020. PMID: 32029129
Stern LK, Selby VN, Kolaitis NA, Boin F, Aras M, Klein L, De Marco T. Heart-lung transplantation: A viable option for connective tissue diseases. Clinical transplantation 2019. PMID: 31867763
DesJardin JT, Manicardi M, Svetlichnaya Y, Kolaitis NA, Papolos AI, Selby VN, Zier LS, Klein L, Aras MA, Yao FY, Roberts JP, De Marco T. Non-Invasive Estimation of Pulmonary Vascular Resistance Improves Portopulmonary Hypertension Screening in Liver Transplant Candidates. Clinical transplantation 2019. PMID: 31074522
Aras MA, Psotka MA, De Marco T. Pulmonary Hypertension Due to Left Heart Disease: an Update. Current cardiology reports 2019. PMID: 31134443
Zhang J, Gajjala S, Agrawal P, Tison GH, Hallock LA, Beussink-Nelson L, Lassen MH, Fan E, Aras MA, Jordan C, Fleischmann KE, Melisko M, Qasim A, Shah SJ, Bajcsy R, Deo RC. Fully Automated Echocardiogram Interpretation in Clinical Practice. Circulation 2018. PMID: 30354459
Aras MA, Teerlink JR. Lung ultrasound: a 'B-line' to the prediction of decompensated heart failure. European heart journal 2016. PMID: 27080198
Aras MA, Aizenman E. Redox regulation of intracellular zinc: molecular signaling in the life and death of neurons. Antioxidants & redox signaling 2011. PMID: 20849376
Aras MA, Saadi RA, Aizenman E. Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia. The European journal of neuroscience 2009. PMID: 20092568
Redman PT, Hartnett KA, Aras MA, Levitan ES, Aizenman E. Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling. The Journal of physiology 2009. PMID: 19622611
Hershfinkel M, Kandler K, Knoch ME, Dagan-Rabin M, Aras MA, Abramovitch-Dahan C, Sekler I, Aizenman E. Intracellular zinc inhibits KCC2 transporter activity. Nature neuroscience 2009. PMID: 19430470
Aras MA, Hara H, Hartnett KA, Kandler K, Aizenman E. Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning. Journal of neurochemistry 2009. PMID: 19453299
Aras MA, Hartnett KA, Aizenman E. Assessment of cell viability in primary neuronal cultures. Current protocols in neuroscience 2008. PMID: 18633999
Chalovich EM, Koike MA, Aras MA, Murphey-Corb M, Wiley CA, Jordan-Sciutto KL. Pocket proteins p107 and p130 exhibit increased expression in macrophages during SIV encephalitis. Neuropathology : official journal of the Japanese Society of Neuropathology 2005. PMID: 16382780
Aras MA, Aizenman E. Obligatory role of ASK1 in the apoptotic surge of K+ currents. Neuroscience letters 2005. PMID: 16006035