Liviu Klein, MD, MS

Education
Fellow, 2009 - Clinical Cardiac Electrophysiology, Northwestern Memorial Hospital
Fellow, 2008 - Advanced Heart Failure and Transplantation, Northwestern Memorial Hospital
Fellow, 2007 - Cardiovascular Disease, Northwestern Memorial Hospital
Fellow, 2005 - Cardiovascular Epidemiology, Northwestern University
MSCI, 2005 - Graduate School, Northwestern University
Resident, 2003 - Internal Medicine, Advocate Illinois Masonic Medical Center
Resident, 2000 - Internal Medicine, University Hospital Bucharest
MD, 1999 - Medicine, Carol Davila School of Medicine
Honors and Awards
  • Sezai Innovative Research Award, International Society for Rotary Blood Pumps, 2016
  • Cardiology Faculty Teaching Award, University of California San Francisco, 2013
  • Larry Jameson Research Award, Northwestern University Feinberg School of Medicine, 2009
  • Outstanding Senior Resident Award, Advocate Illinois Masonic Medical Center, 2003
Websites
Publications

  1. Cowger JA, Basir MB, Baran DA, Hayward CS, Rangaswami J, Walton A, Tita C, Minear S, Hakemi E, Klein L, Cheng R, Wu R, Mohanty BD, Heuring JJ, Neely E, Shah P, Aortix CRS Pilot Study Investigators. Safety and Performance of the Aortix Device in Acute Decompensated Heart Failure and Cardiorenal Syndrome. JACC. Heart failure 2023. PMID: 37804307


  2. Trachtenberg B, Jennings D, Grafton G, Loyaga-Rendon R, Cogswell R, Klein L, Shah P, Kiernan M, Vorovich E, Cowger J. Corrigendum to "HFSA Expert Consensus Statement on the Medical Management of Patients on Durable Mechanical Circulatory Support": Journal of Cardiac Failure Vol. 29 No. 4, pp. 479-502. Journal of cardiac failure 2023. PMID: 37414594


  3. Fiedler AG, Klein L, DeMarco T, Kouretas P, Smith JW. Comment on: Detection and Management of HLA Sensitization in Candidates for Adult Heart Transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023. PMID: 37088342


  4. Hahn EA, Allen LA, Lee CS, Denfeld QE, Stehlik J, Cella D, Lindenfeld J, Teuteberg JJ, McIlvennan CK, Kiernan MS, Beiser DG, Walsh MN, Adler ED, Ruo B, Kirklin JK, Klein L, Bedjeti K, Cummings PD, Burns JL, Vela AM, Grady KL. PROMIS� Physical, Mental and Social Health Outcomes Improve from Before to Early After LVAD Implant: Findings from the Mechanical Circulatory Support: Measures of Adjustment and Quality of Life (MCS A-QOL) Study. Journal of cardiac failure 2023. PMID: 37004864


  5. Trachtenberg B, Cowger J, Jennings DL, Grafton G, Loyaga-Rendon R, Cogswell R, Klein L, Shah P, Kiernan M, Vorovich E. HFSA Expert Consensus Statement on the Medical Management of Patients on Durable Mechanical Circulatory Support. Journal of cardiac failure 2023. PMID: 36828256


  6. Hahn EA, Walsh MN, Allen LA, Lee CS, Denfeld QE, Teuteberg JJ, Beiser DG, McIlvennan CK, Lindenfeld J, Klein L, Adler ED, Stehlik J, Ruo B, Bedjeti K, Cummings PD, Vela AM, Grady KL. Validity of Patient-Reported Outcomes Measurement Information System Physical, Mental, and Social Health Measures After Left Ventricular Assist Device Implantation and Implications for Patient Care. Circulation. Cardiovascular quality and outcomes 2023. PMID: 36752104


  7. Aras MA, Abreau S, Mills H, Radhakrishnan L, Klein L, Mantri N, Rubin B, Barrios J, Chehoud C, Kogan E, Gitton X, Nnewihe A, Quinn D, Bridges C, Butte AJ, Olgin JE, Tison GH. Electrocardiogram Detection of Pulmonary Hypertension Using Deep Learning. Journal of cardiac failure 2023. PMID: 36706977


  8. Guichard JL, Cowger JA, Chaparro SV, Kiernan MS, Mullens W, Mahr C, Mullin C, Forouzan O, Hiivala NJ, Sauerland A, Leadley K, Klein L, Greenville, South Carolina; Detroit, Michigan; Miami, Florida; Boston, Massachusetts; Genk, Belgium;. Rationale and Design of the Proactive-HF Trial for Managing Patients With NYHA Class III Heart Failure by Using the Combined Cordella Pulmonary Artery Sensor and the Cordella Heart Failure System. Journal of cardiac failure 2022. PMID: 36191758


  9. Fudim M, Shahid I, Emani S, Klein L, Dupuy-McCauley KL, Zieroth S, Mentz RJ. Evaluation and Treatment of Central Sleep Apnea in Patients with Heart Failure. Current problems in cardiology 2022. PMID: 35995244


  10. Shandhi MMH, Fan J, Heller J, Etemadi M, Klein L, Inan O. Estimation of Changes in Intracardiac Hemodynamics Using Wearable Seismocardiography and Machine Learning in Patients with Heart Failure: A Feasibility Study. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35100106


  11. Fudim M, Fail PS, Litwin SE, Shaburishvili T, Goyal P, Hummel SL, Borlaug BA, Mohan RC, Patel RB, Mitter SS, Klein L, Rocha-Singh K, Patel MR, Reddy VY, Burkhoff D, Shah SJ. Endovascular ablation of the right greater splanchnic nerve in heart failure with preserved ejection fraction: early results of the REBALANCE-HF trial roll-in cohort. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35598154


  12. Jering KS, Campagnari C, Claggett B, Adler E, Klein L, Ahmad FS, Voors AA, Solomon S, Yagil A, Greenberg B. Improving Clinical Trial Efficiency Using a Machine Learning Based Risk Score to Enrich Study Populations. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35508918


  13. Haring B, Hunt RP, Manson JE, LaMonte MJ, Klein L, Allison MA, Wild RA, Wallace RB, Shadyab AH, Breathett K, Eaton C, Wassertheil-Smoller S, Shimbo D. Blood Pressure Variability and Heart Failure Hospitalization: Results From the Women's Health Initiative. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35525685


  14. Hayward C, Adachi I, Baudart S, Davis E, Feller ED, Kinugawa K, Klein L, Li S, Lorts A, Mahr C, Mathew J, Morshuis M, Müller M, Ono M, Pagani FD, Pappalardo F, Rich J, Robson D, Rosenthal DN, Saeed D, Salerno C, Sauer AJ, Schlöglhofer T, Tops L, VanderPluym C. Global best practices consensus: Long-term management of patients with hybrid centrifugal flow left ventricular assist device support. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35624053


  15. Hernandez AF, Albert NM, Allen LA, Ahmed R, Averina V, Boehmer JP, Cowie MR, Chien CV, Galvao M, Klein L, Kwan B, Lam CSP, Ruble SB, Stolen CM, Stein K, MANAGE-HF Study. Multiple cArdiac seNsors for mAnaGEment of Heart Failure (MANAGE-HF) - Phase I Evaluation of the Integration and Safety of the HeartLogic Multisensor Algorithm in Patients With Heart Failure. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35460884


  16. Neill L, Etemadi M, Klein L, Inan OT. Novel Noninvasive Biosensors and Artificial Intelligence for Optimized Heart Failure Management. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35411315


  17. Banerjee R, Lo M, Klein L, Aras M, Logan AC. Anthracyclines in a patient with acute leukemia and severe cardiomyopathy requiring mechanical support: A case report. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34846217


  18. Klein L. Is There a Logic in Using Device-Based Algorithms to Prevent Heart Failure Decompensations? 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34634918


  19. Kalantarian S, Åström Aneq M, Svetlichnaya J, Sharma S, Vittinghoff E, Klein L, Scheinman MM. Long-Term Electrocardiographic and Echocardiographic Progression of Arrhythmogenic Right Ventricular Cardiomyopathy and Their Correlation With Ventricular Tachyarrhythmias. Circulation. Heart failure 2021. PMID: 34550004


  20. Darden D, Ammirati E, Brambatti M, Lin A, Hsu JC, Shah P, Perna E, Cikes M, Gjesdal G, Potena L, Masetti M, Jakus N, Van De Heyning C, De Bock D, Brugts JJ, Russo CF, Veenis JF, Rega F, Cipriani M, Frigerio M, Liviu K, Hong KN, Adler E, Braun OÖ. Cardiovascular implantable electronic device therapy in patients with left ventricular assist devices: insights from TRAViATA. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34437934


  21. Tison GH, Avram R, Nah G, Klein L, Howard BV, Allison MA, Casanova R, Blair RH, Breathett K, Foraker RE, Olgin JE, Parikh NI. Predicting incident heart failure in women with machine learning: The Women's Health Initiative Cohort. The Canadian journal of cardiology 2021. PMID: 34400272


  22. Quesada O, Shandhi MMH, Beach S, Dowling S, Tandon D, Heller J, Etemadi M, Roy S, Gonzalez Velez JM, Inan OT, Klein L. Use of Ballistocardiography to Monitor Cardiovascular Hemodynamics in Preeclampsia. Women's health reports (New Rochelle, N.Y.) 2021. PMID: 33937907


  23. . Two-Year Follow Up of the LATERAL Clinical Trial: A Focus on Adverse Events. Circulation. Heart failure 2021. PMID: 33866829


  25. LaMonte MJ, Larson JC, Manson JE, Bellettiere J, Lewis CE, LaCroix AZ, Bea JW, Johnson KC, Klein L, Noel CA, Stefanick ML, Wactawski-Wende J, Eaton CB. Association of Sedentary Time and Incident Heart Failure Hospitalization in Postmenopausal Women. Circulation. Heart failure 2020. PMID: 33228398


  26. Breathett K, Kohler LN, Eaton CB, Franceschini N, Garcia L, Klein L, Martin LW, Ochs-Balcom HM, Shadyab AH, Cené CW. When the At-Risk Do Not Develop Heart Failure: Understanding Positive Deviance Among Postmenopausal African-American and Hispanic Women. Journal of cardiac failure 2020. PMID: 33232822


  27. Lam PH, Barac A, Nohria A, Reding KW, Najjar SS, Fonarow GC, Pan K, Sheriff H, Morgan CJ, Chlebowski RT, Klein L, Eaton CB, Howard BV, Ahmed A, Mohammed SF. Temporal Associations and Outcomes of Breast Cancer and Heart Failure in Postmenopausal Women. JACC. CardioOncology 2020. PMID: 34396268


  28. Ammirati E, Brambatti M, Braun OÖ, Shah P, Cipriani M, Bui QM, Veenis J, Lee E, Xu R, Hong KN, Van de Heyning CM, Perna E, Timmermans P, Cikes M, Brugts JJ, Veronese G, Minto J, Smith S, Gjesdal G, Gernhofer YK, Partida C, Potena L, Masetti M, Boschi S, Loforte A, Jakus N, Milicic D, Nilsson J, De Bock D, Sterken C, Van den Bossche K, Rega F, Tran H, Singh R, Montomoli J, Mondino M, Greenberg B, Russo CF, Pretorius V, Liviu K, Frigerio M, Adler ED. Outcome of patients on heart transplant list treated with a continuous-flow left ventricular assist device: Insights from the TRans-Atlantic registry on VAd and TrAnsplant (TRAViATA). International journal of cardiology 2020. PMID: 32950592


  29. Hasan Shandhi MM, Aras M, Wynn S, Fan J, Heller JA, Etemadi M, Klein L, Inan OT. Cardiac Function Monitoring for Patients Undergoing Cancer Treatments Using Wearable Seismocardiography: A Proof-of-Concept Study. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2020. PMID: 33018894


  30. Shandhi MMH, Hersek S, Fan J, Sander E, Marco T, Heller JA, Etemadi M, Klein L, Inan OT. Wearable Patch Based Estimation of Oxygen Uptake and Assessment of Clinical Status during Cardiopulmonary Exercise Testing in Patients with Heart Failure. Journal of cardiac failure 2020. PMID: 32473379


  31. Semiz B, Inan O, Hersek S, Pouyan MB, Partida C, Arroyo LB, Selby V, Wieselthaler G, Rehg J, Klein L. Detecting Suspected Pump Thrombosis in Left Ventricular Assist Devices via Acoustic Analysis. IEEE journal of biomedical and health informatics 2020. PMID: 31940570


  32. Stern LK, Selby VN, Kolaitis NA, Boin F, Aras M, Klein L, De Marco T. Heart-lung transplantation: A viable option for connective tissue diseases. Clinical transplantation 2019. PMID: 31867763


  33. Adler ED, Voors AA, Klein L, Macheret F, Braun OO, Urey MA, Zhu W, Sama I, Tadel M, Campagnari C, Greenberg B, Yagil A. Improving risk prediction in heart failure using machine learning. European journal of heart failure 2019. PMID: 31721391


  34. Liu L, Klein L, Eaton C, Panjrath G, Martin LW, Chae CU, Greenland P, Lloyd-Jones DM, Wactawski-Wende J, Manson JE. Menopausal Hormone Therapy and Risks of First Hospitalized Heart Failure and Its Subtypes During the Intervention and Extended Postintervention Follow-up of the Women's Health Initiative Randomized Trials. Journal of cardiac failure 2019. PMID: 31536806


  35. Rosenthal DG, Parwani P, Murray TO, Petek BJ, Benn BS, De Marco T, Gerstenfeld EP, Janmohamed M, Klein L, Lee BK, Moss JD, Scheinman MM, Hsia HH, Selby V, Koth LL, Pampaloni MH, Zikherman J, Vedantham V. Long-Term Corticosteroid-Sparing Immunosuppression for Cardiac Sarcoidosis. Journal of the American Heart Association 2019. PMID: 31538835


  36. Aydemir VB, Nagesh S, Shandhi M, Fan J, Klein L, Etemadi M, Heller JA, Inan O, Rehg JM. Classification of Decompensated Heart Failure from Clinical and Home Ballistocardiography. IEEE transactions on bio-medical engineering 2019. PMID: 31425011


  37. Abraham J, McCann P, Wang L, Schnell Heringer A, Paulsen J, Chappell J, Remick J, Westerdahl D, Lewis R, Callis K, Spinelli KJ, Klein L. Internal Jugular Vein as Alternative Access for Implantation of a Wireless Pulmonary Artery Pressure Sensor. Circulation. Heart failure 2019. PMID: 31525097


  38. Cardona-Guarache R, Åström-Aneq M, Oesterle A, Asirvatham R, Svetlichnaya J, Marcus GM, Gerstenfeld EP, Klein L, Scheinman MM. Atrial arrhythmias in patients with arrhythmogenic right ventricular cardiomyopathy: Prevalence, echocardiographic predictors, and treatment. Journal of cardiovascular electrophysiology 2019. PMID: 31310380


  39. DesJardin JT, Manicardi M, Svetlichnaya Y, Kolaitis NA, Papolos AI, Selby VN, Zier LS, Klein L, Aras MA, Yao FY, Roberts JP, De Marco T. Non-Invasive Estimation of Pulmonary Vascular Resistance Improves Portopulmonary Hypertension Screening in Liver Transplant Candidates. Clinical transplantation 2019. PMID: 31074522


  40. McGee E, Danter M, Strueber M, Mahr C, Mokadam NA, Wieselthaler G, Klein L, Lee S, Boeve T, Maltais S, Pretorius GV, Adler E, Vassiliades T, Cheung A. Evaluation of a lateral thoracotomy implant approach for a centrifugal-flow left ventricular assist device: The LATERAL clinical trial. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2019. PMID: 30945636


  41. Arnaout R, Nah G, Marcus G, Tseng Z, Foster E, Harris IS, Divanji P, Klein L, Gonzalez J, Parikh N. Pregnancy complications and premature cardiovascular events among 1.6 million California pregnancies. Open heart 2019. PMID: 30997125


  42. Moss JD, Oesterle A, Raiman M, Flatley EE, Beaser AD, Jeevanandam V, Klein L, Ota T, Wieselthaler G, Uriel N, Tung R. Feasibility and utility of intraoperative epicardial scar characterization during left ventricular assist device implantation. Journal of cardiovascular electrophysiology 2018. PMID: 30516301


  43. LaMonte MJ, Manson JE, Chomistek AK, Larson JC, Lewis CE, Bea JW, Johnson KC, Li W, Klein L, LaCroix AZ, Stefanick ML, Wactawski-Wende J, Eaton CB. Physical Activity and Incidence of Heart Failure in Postmenopausal Women. JACC. Heart failure 2018. PMID: 30196073


  44. Breathett K, Leng I, Foraker RE, Abraham WT, Coker L, Whitfield KE, Shumaker S, Manson JE, Eaton CB, Howard BV, Ijioma N, Cené CW, Martin LW, Johnson KC, Klein L. Risk Factor Burden, Heart Failure, and Survival in Women of Different Ethnic Groups: Insights From the Women's Health Initiative. Circulation. Heart failure 2018. PMID: 29716899


  45. Pandey A, Omar W, Ayers C, LaMonte M, Klein L, Allen NB, Kuller LH, Greenland P, Eaton CB, Gottdiener JS, Lloyd-Jones DM, Berry JD. Sex and Race Differences in Lifetime Risk of Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction. Circulation 2018. PMID: 29352072


  46. Inan OT, Baran Pouyan M, Javaid AQ, Dowling S, Etemadi M, Dorier A, Heller JA, Bicen AO, Roy S, De Marco T, Klein L. Novel Wearable Seismocardiography and Machine Learning Algorithms Can Assess Clinical Status of Heart Failure Patients. Circulation. Heart failure 2018. PMID: 29330154


  47. Klein L. (Re)Discovering the Neurohormonal and Hemodynamic Duality of Heart Failure. Journal of the American College of Cardiology 2017. PMID: 28982502


  48. Hall PS, Nah G, Howard BV, Lewis CE, Allison MA, Sarto GE, Waring ME, Jacobson LT, Manson JE, Klein L, Parikh NI. Reproductive Factors and Incidence of Heart Failure Hospitalization in the Women's Health Initiative. Journal of the American College of Cardiology 2017. PMID: 28521890


  49. Pandey A, LaMonte M, Klein L, Ayers C, Psaty BM, Eaton CB, Allen NB, de Lemos JA, Carnethon M, Greenland P, Berry JD. Relationship Between Physical Activity, Body Mass Index, and Risk of Heart Failure. Journal of the American College of Cardiology 2017. PMID: 28254175


  50. Brondfield MN, Reid MJ, Rutishauser RL, Cope JR, Tang J, Ritter JM, Matanock A, Ali I, Doernberg SB, Hilts-Horeczko A, DeMarco T, Klein L, Babik JM. Disseminated Acanthamoeba infection in a heart transplant recipient treated successfully with a miltefosine-containing regimen: Case report and review of the literature. Transplant infectious disease : an official journal of the Transplantation Society 2017. PMID: 28067969


  51. Cowie MR, Simon M, Klein L, Thokala P. The cost-effectiveness of real-time pulmonary artery pressure monitoring in heart failure patients: a European perspective. European journal of heart failure 2017. PMID: 28176424


  52. Eaton CB, Pettinger M, Rossouw J, Martin LW, Foraker R, Quddus A, Liu S, Wampler NS, Hank Wu WC, Manson JE, Margolis K, Johnson KC, Allison M, Corbie-Smith G, Rosamond W, Breathett K, Klein L. Risk Factors for Incident Hospitalized Heart Failure With Preserved Versus Reduced Ejection Fraction in a Multiracial Cohort of Postmenopausal Women. Circulation. Heart failure 2016. PMID: 27682440


  53. Sack KL, Baillargeon B, Acevedo-Bolton G, Genet M, Rebelo N, Kuhl E, Klein L, Weiselthaler GM, Burkhoff D, Franz T, Guccione JM. Partial LVAD restores ventricular outputs and normalizes LV but not RV stress distributions in the acutely failing heart in silico. The International journal of artificial organs 2016. PMID: 27646633


  55. Klein L, Greenberg BH, Konstam MA, Gregory D, Kociol RD, Johnson MR, de Marco T. Activities and Compensation of Advanced Heart Failure Specialists: Results of the Heart Failure Society of America (HFSA) Survey. Journal of cardiac failure 2015. PMID: 26362520


  56. Rogers SE, Klein L, Perissinotto CM. The importance of cognitive assessment before ventricular device placement: a teachable moment. JAMA internal medicine 2015. PMID: 25822770


  57. Etemadi M, Inan OT, Heller JA, Hersek S, Klein L, Roy S. A Wearable Patch to Enable Long-Term Monitoring of Environmental, Activity and Hemodynamics Variables. IEEE transactions on biomedical circuits and systems 2015. PMID: 25974943


  58. Donneyong MM, Hornung CA, Taylor KC, Baumgartner RN, Myers JA, Eaton CB, Gorodeski EZ, Klein L, Martin LW, Shikany JM, Song Y, Li W, Manson JE. Risk of heart failure among postmenopausal women: a secondary analysis of the randomized trial of vitamin D plus calcium of the women's health initiative. Circulation. Heart failure 2014. PMID: 25398967


  59. Wiens AD, Etemadi M, Roy S, Klein L, Inan OT. Toward continuous, noninvasive assessment of ventricular function and hemodynamics: wearable ballistocardiography. IEEE journal of biomedical and health informatics 2014. PMID: 25265619


  60. Klein L, Hsia H. Sudden cardiac death in heart failure. Cardiology clinics 2014. PMID: 24286584


  61. Etemadi M, Hersek S, Tseng JM, Rabbani N, Heller JA, Roy S, Klein L, Inan OT. Tracking clinical status for heart failure patients using ballistocardiography and electrocardiography signal features. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2014. PMID: 25571162


  62. Wiens A, Etemadi M, Klein L, Roy S, Inan OT. Wearable ballistocardiography: preliminary methods for mapping surface vibration measurements to whole body forces. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2014. PMID: 25571158


  63. Sridharan L, Klein L. Prognostic factors in patients hospitalized for heart failure. Current heart failure reports 2013. PMID: 24122287


  64. Perez MV, Wang PJ, Larson JC, Soliman EZ, Limacher M, Rodriguez B, Klein L, Manson JE, Martin LW, Prineas R, Connelly S, Hlatky M, Wassertheil-Smoller S, Stefanick ML. Risk factors for atrial fibrillation and their population burden in postmenopausal women: the Women's Health Initiative Observational Study. Heart (British Cardiac Society) 2013. PMID: 23756655


  65. Perez MV, Wang PJ, Larson JC, Virnig BA, Cochrane B, Curb JD, Klein L, Manson JE, Martin LW, Robinson J, Wassertheil-Smoller S, Stefanick ML. Effects of postmenopausal hormone therapy on incident atrial fibrillation: the Women's Health Initiative randomized controlled trials. Circulation. Arrhythmia and electrophysiology 2012. PMID: 23169946


  67. Avery CL, Sethupathy P, Buyske S, He Q, Lin DY, Arking DE, Carty CL, Duggan D, Fesinmeyer MD, Hindorff LA, Jeff JM, Klein L, Patton KK, Peters U, Shohet RV, Sotoodehnia N, Young AM, Kooperberg C, Haiman CA, Mohlke KL, Whitsel EA, North KE. Fine-mapping and initial characterization of QT interval loci in African Americans. PLoS genetics 2012. PMID: 22912591


  68. Eaton CB, Abdulbaki AM, Margolis KL, Manson JE, Limacher M, Klein L, Allison MA, Robinson JG, Curb JD, Martin LA, Liu S, Howard BV. Racial and ethnic differences in incident hospitalized heart failure in postmenopausal women: the Women's Health Initiative. Circulation 2012. PMID: 22753306


  70. Klein L. Rivaroxaban reduced stroke and systemic embolism compared with warfarin in nonvalvular AF. Annals of internal medicine 2012. PMID: 22250165


  71. Shah RU, Winkleby MA, Van Horn L, Phillips LS, Eaton CB, Martin LW, Rosal MC, Manson JE, Ning H, Lloyd-Jones DM, Klein L. Education, income, and incident heart failure in post-menopausal women: the Women's Health Initiative Hormone Therapy Trials. Journal of the American College of Cardiology 2011. PMID: 21939829


  72. Klein L, Grau-Sepulveda MV, Bonow RO, Hernandez AF, Williams MV, Bhatt DL, Fonarow GC. Quality of care and outcomes in women hospitalized for heart failure. Circulation. Heart failure 2011. PMID: 21862732


  74. Svetlichnaya J, Klein L. Atrial fibrillation in elderly patients with heart failure: convergence of two cardiovascular epidemics in the 21st Century. Expert review of cardiovascular therapy 2011. PMID: 21809972


  75. Tempelhof MW, Klein L, Cotts WG, Benzuly KH, Davidson CJ, Meyers SN, McCarthy PM, Malaisrie CS, McGee EC, Beohar N. Clinical experience and patient outcomes associated with the TandemHeart percutaneous transseptal assist device among a heterogeneous patient population. ASAIO journal (American Society for Artificial Internal Organs : 1992) 2011. PMID: 21546824


  76. Shah RU, Tsai V, Klein L, Heidenreich PA. Characteristics and outcomes of very elderly patients after first hospitalization for heart failure. Circulation. Heart failure 2011. PMID: 21467294


  78. Shah RU, Klein L, Lloyd-Jones DM. Heart failure in women: epidemiology, biology and treatment. Women's health (London, England) 2009. PMID: 19702451


  80. Klein L, O'connell JB. Thromboembolic risk in the patient with heart failure. Current treatment options in cardiovascular medicine 2007. PMID: 17761116


  82. Gheorghiade M, Zannad F, Sopko G, Klein L, Piña IL, Konstam MA, Massie BM, Roland E, Targum S, Collins SP, Filippatos G, Tavazzi L. Acute heart failure syndromes: current state and framework for future research. Circulation 2005. PMID: 16365214


  83. De Luca L, Klein L, Udelson JE, Orlandi C, Sardella G, Fedele F, Gheorghiade M. Hyponatremia in patients with heart failure. The American journal of cardiology 2005. PMID: 16399089


  86. Klein L, Gheorghiade M. Coronary artery disease and prevention of heart failure. The Medical clinics of North America 2004. PMID: 15331314


  87. Danciu SC, Klein L, Hosseini MM, Ibrahim L, Coyle BW, Kehoe RF. A predictive model for survival after in-hospital cardiopulmonary arrest. Resuscitation 2004. PMID: 15246581


  88. Klein L, Galvez A, Klein O, Chediak J. Warfarin-induced limb gangrene in the setting of lung adenocarcinoma. American journal of hematology 2004. PMID: 15164386


  90. Klein L, Gheorghiade M. Management of the patient with diabetes mellitus and myocardial infarction: clinical trials update. The American journal of medicine 2004. PMID: 15019863


  91. Piccini JP, Klein L, Gheorghiade M, Bonow RO. New insights into diastolic heart failure: role of diabetes mellitus. The American journal of medicine 2004. PMID: 15019864


  92. Gheorghiade M, Klein L, Stone NJ, Bonow RO, Kim RJ. Improvement in the function of hibernating myocardium in a patient with heart failure due to coronary artery disease receiving high-dose simvastatin. Italian heart journal : official journal of the Italian Federation of Cardiology 2004. PMID: 15086148


  93. Klein L, O'Connor CM, Gattis WA, Zampino M, de Luca L, Vitarelli A, Fedele F, Gheorghiade M. Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerations. The American journal of cardiology 2003. PMID: 12729848


  94. Jain P, Massie BM, Gattis WA, Klein L, Gheorghiade M. Current medical treatment for the exacerbation of chronic heart failure resulting in hospitalization. American heart journal 2003. PMID: 12594447


  95. Klein L, Gheorghiade M. Therapeutic strategies for patients hospitalized with worsening heart failure. Italian heart journal : official journal of the Italian Federation of Cardiology 2003. PMID: 12762267


  96. Gheorghiade M, Gattis WA, Klein L. OPTIME in CHF trial: rethinking the use of inotropes in the management of worsening chronic heart failure resulting in hospitalization. European journal of heart failure 2003. PMID: 12559209


  97. Borrello F, Beahan M, Klein L, Gheorghiade M. Reappraisal of beta-blocker therapy in the acute and chronic post-myocardial infarction period. Reviews in cardiovascular medicine 2003. PMID: 14564230