Joshua Barrios, PhD, BS

Assistant Professor

Cardiology UCSF Health

Dr. Barrios earned his Ph.D. in Neuroscience from the University of Utah, where his work focused on dopaminergic modulation of sensorimotor behavior. His interest in computational and systems neuroscience and love for engineering naturally led him to study artificial deep neural networks. Currently, his work in the Tison lab involves development of deep learning systems for clinical and biomedical applications.

Research interests: Dr. Barrios brings together expertise in physiology, systems neuroscience, and advanced machine learning algorithms to automate clinical processes, expand diagnostic utility of existing clinical tests, and elucidate mechanisms of disease. He has developed multiple deep learning based systems for automated detection of diseases such as mitral valve prolapse, hypertrophic cardiomyopathy, and pulmonary hypertension from electrocardiograms, echocardiograms, and other clinical data modalities. His work aims to improve the sensitivity of our health system as a whole, increasing early detection of disease and the efficacy of preventative care.

Education
Ph.D., 11/2019 - Neuroscience, University of Utah
Publications

  1. Barrios JP, Seshadri MR, Tison GH. Artificial Intelligence to Complement, Not Replace, Clinical Knowledge: Reading Between the Lines. JACC. CardioOncology 2024. PMID: 38774016


  2. Antiperovitch P, Mortara D, Barrios J, Avram R, Yee K, Khaless AN, Cristal A, Tison G, Olgin J. Continuous Atrial Fibrillation Monitoring From Photoplethysmography: Comparison Between Supervised Deep Learning and Heuristic Signal Processing. JACC. Clinical electrophysiology 2024. PMID: 38340117


  3. Siontis KC, Abreau S, Attia ZI, Barrios JP, Dewland TA, Agarwal P, Balasubramanyam A, Li Y, Lester SJ, Masri A, Wang A, Sehnert AJ, Edelberg JM, Abraham TP, Friedman PA, Olgin JE, Noseworthy PA, Tison GH. Patient-Level Artificial Intelligence-Enhanced Electrocardiography in Hypertrophic Cardiomyopathy: Longitudinal Treatment and Clinical Biomarker Correlations. JACC. Advances 2023. PMID: 38076758


  4. Avram R, Olgin JE, Ahmed Z, Verreault-Julien L, Wan A, Barrios J, Abreau S, Wan D, Gonzalez JE, Tardif JC, So DY, Soni K, Tison GH. CathAI: fully automated coronary angiography interpretation and stenosis estimation. NPJ digital medicine 2023. PMID: 37568050


  5. Tison GH, Abreau S, Barrios J, Lim LJ, Yang M, Crudo V, Shah DJ, Nguyen T, Hu G, Dixit S, Nah G, Arya F, Bibby D, Lee Y, Delling FN. Identifying Mitral Valve Prolapse at Risk for Arrhythmias and Fibrosis From Electrocardiograms Using Deep Learning. JACC. Advances 2023. PMID: 37936601


  6. Higuchi S, Li R, Gerstenfeld EP, Liem LB, Im SI, Kalantarian S, Ansari M, Abreau S, Barrios J, Scheinman MM, Tison GH. Identification of supraventricular tachycardia mechanisms with surface electrocardiograms using a convolutional neural network. Heart rhythm O2 2023. PMID: 37645266


  7. Avram R, Barrios JP, Abreau S, Goh CY, Ahmed Z, Chung K, So DY, Olgin JE, Tison GH. Automated Assessment of Cardiac Systolic Function From Coronary Angiograms With Video-Based Artificial Intelligence Algorithms. JAMA cardiology 2023. PMID: 37163297


  8. Chaudhari GR, Mayfield JJ, Barrios JP, Abreau S, Avram R, Olgin JE, Tison GH. Deep learning augmented ECG analysis to identify biomarker-defined myocardial injury. Scientific Reports 2023. PMID: 36849487


  9. Aras MA, Abreau S, Mills H, Radhakrishnan L, Klein L, Mantri N, Rubin B, Barrios J, Chehoud C, Kogan E, Gitton X, Nnewihe A, Quinn D, Bridges C, Butte AJ, Olgin JE, Tison GH. Electrocardiogram Detection of Pulmonary Hypertension Using Deep Learning. Journal of cardiac failure 2023. PMID: 36706977


  10. Barrios JP, Tison GH. Advancing cardiovascular medicine with machine learning: Progress, potential, and perspective. Cell reports. Medicine 2022. PMID: 36543095


  11. Tison GH, Barrios J, Avram R, Kuhar P, Bostjancic B, Marcus GM, Pletcher MJ, Olgin JE. Worldwide physical activity trends since COVID-19 onset. The Lancet. Global health 2022. PMID: 36057269


  12. Elias P, Poterucha TJ, Rajaram V, Moller LM, Rodriguez V, Bhave S, Hahn RT, Tison G, Abreau SA, Barrios J, Torres JN, Hughes JW, Perez MV, Finer J, Kodali S, Khalique O, Hamid N, Schwartz A, Homma S, Kumaraiah D, Cohen DJ, Maurer MS, Einstein AJ, Nazif T, Leon MB, Perotte AJ. Deep Learning Electrocardiographic Analysis for Detection of Left-Sided Valvular Heart Disease. Journal of the American College of Cardiology 2022. PMID: 35926935


  13. Vasudevan D, Liu YC, Barrios JP, Wheeler MK, Douglass AD, Dorsky RI. Regenerated interneurons integrate into locomotor circuitry following spinal cord injury. Volume 342. Experimental neurology 2021. PMID: 33957107


  14. Barrios JP, Wang WC, England R, Reifenberg E, Douglass AD. Hypothalamic Dopamine Neurons Control Sensorimotor Behavior by Modulating Brainstem Premotor Nuclei in Zebrafish. Volume 30 of Issue 23. Current biology : CB 2020. PMID: 33007241


  15. Wee CL, Nikitchenko M, Wang WC, Luks-Morgan SJ, Song E, Gagnon JA, Randlett O, Bianco IH, Lacoste AMB, Glushenkova E, Barrios JP, Schier AF, Kunes S, Engert F, Douglass AD. Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets. Volume 22 of Issue 9. Nature neuroscience 2019. PMID: 31358991


  16. Julien DP, Chan AW, Barrios J, Mathiaparanam J, Douglass A, Wolman MA, Sagasti A. Zebrafish expression reporters and mutants reveal that the IgSF cell adhesion molecule Dscamb is required for feeding and survival. Volume 32 of Issue 4. Journal of neurogenetics 2018. PMID: 30204029


  17. Gao J, Stevenson TJ, Douglass AD, Barrios JP, Bonkowsky JL. The Midline Axon Crossing Decision Is Regulated through an Activity-Dependent Mechanism by the NMDA Receptor. Volume 5 of Issue 2. eNeuro 2018. PMID: 29766040


  18. McPherson AD, Barrios JP, Luks-Morgan SJ, Manfredi JP, Bonkowsky JL, Douglass AD, Dorsky RI. Motor Behavior Mediated by Continuously Generated Dopaminergic Neurons in the Zebrafish Hypothalamus Recovers after Cell Ablation. Volume 26 of Issue 2. Current biology : CB 2016. PMID: 26774784


  19. Son JH, Keefe MD, Stevenson TJ, Barrios JP, Anjewierden S, Newton JB, Douglass AD, Bonkowsky JL. Transgenic FingRs for Live Mapping of Synaptic Dynamics in Genetically-Defined Neurons. Volume 6. Scientific Reports 2016. PMID: 26728131


  20. Schoborg T, Rickels R, Barrios J, Labrador M. Chromatin insulator bodies are nuclear structures that form in response to osmotic stress and cell death. Volume 202 of Issue 2. The Journal of cell biology 2013. PMID: 23878275