Jan Christoph, PhD, MSc

Assistant Professor

Jan Christoph studies the heart from a complex and dynamical systems perspective. He is interested in arrhythmia mechanisms and the coupling between electrophysiology and tissue mechanics, as well as electromechanical feedback. He uses computational methods, artificial intelligence and high-resolution imaging to study the heart.

Publications

  1. Hua Z, Patlatzoglou K, Kappadan V, Sun X, Lebert J, Efstathiou P, Tonko JB, Lee IE, Sohi A, Agha-Jaffar D, Mohamed N, Abdelghani Y, Onslow O, Baranwal T, Pyman E, Guichard JB, Ripplinger CM, Luther S, Peters NS, Christoph J, Ng FS. AI-enabled motion artifact correction to replace emission- and excitation-ratiometry in cardiac optical mapping: A proof-of-concept study. Cardiovascular research 2026. PMID: 42082431


  2. Chowdhary S, Lebert J, Dickman S, Manetta M, Gordon C, Christoph J. Panoramic voltage-sensitive optical mapping of contracting hearts using cooperative multiview motion tracking with 12 cameras. The Journal of physiology 2026. PMID: 41804229


  3. Nimani S, Bains S, Alerni N, Ördög B, Horváth A, Matas L, Louradour J, Giammarino L, Tester DJ, Beslac O, Lopez R, Meier S, Egle M, Christoforou N, Barbieri M, Vashanthakumar V, Perez-Feliz S, Parodi C, Garcia Casalta LG, Kim CSJ, Zhou W, Ye D, Jurgensen J, Barry MA, Bego M, Keyes L, Owens J, Pinkstaff J, Christoph J, Zehender M, Brunner M, Heijman J, Casoni D, Praz F, Haeberlin A, Brooks G, Ackerman MJ, Odening KE. AAV9-mediated KCNH2 suppression-replacement gene therapy in a transgenic rabbit model of type 1 short QT syndrome. European heart journal 2025. PMID: 40884219


  4. Kappadan V, Hua Z, Efstathiou P, Lebert J, Sohi A, Agha-Jaffar D, Tonko JB, Sun X, Mohamed N, Abdelghani Y, Peters NS, Christoph J, Ng FS. Differential response to acute ischemia between isolated contracting hearts and hearts perfused with excitation-contraction uncouplers. American journal of physiology. Heart and circulatory physiology 2025. PMID: 41212552


  5. Baranwal T, Lebert J, Christoph J. Dreaming of electrical waves: Generative modeling of cardiac excitation waves using diffusion models. APL machine learning 2024. PMID: 39364376


  6. Christoph J, Ripplinger CM. Paralysis by analysis: Overcoming cardiac contraction with computer vision. Proceedings of the National Academy of Sciences of the United States of America 2023. PMID: 37792520


  7. Kappadan V, Sohi A, Parlitz U, Luther S, Uzelac I, Fenton F, Peters NS, Christoph J, Ng FS. Optical mapping of contracting hearts. The Journal of physiology 2023. PMID: 36866700


  8. M?nkler P, Klatt N, Scherschel K, Kuklik P, Jungen C, Cavus E, Eickholt C, Christoph J, Lemoine MD, Christ T, Willems S, Riedel R, Kirchhof P, Meyer C. Repolarization indicates electrical instability in ventricular arrhythmia originating from papillary muscle. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2023. PMID: 35989424


  10. Lebert J, Ravi N, Kensah G, Christoph J. Real-Time Optical Mapping of Contracting Cardiac Tissues With GPU-Accelerated Numerical Motion Tracking. Frontiers in cardiovascular medicine 2022. PMID: 35686036


  11. Lebert J, Ravi N, Fenton FH, Christoph J. Rotor Localization and Phase Mapping of Cardiac Excitation Waves Using Deep Neural Networks. Frontiers in physiology 2021. PMID: 34975536


  12. Vogt M, Schulz B, Wagdi A, Lebert J, van Belle GJ, Christoph J, Bruegmann T, Patejdl R. Direct optogenetic stimulation of smooth muscle cells to control gastric contractility. Theranostics 2021. PMID: 33859764


  14. Kappadan V, Telele S, Uzelac I, Fenton F, Parlitz U, Luther S, Christoph J. High-Resolution Optical Measurement of Cardiac Restitution, Contraction, and Fibrillation Dynamics in Beating vs. Blebbistatin-Uncoupled Isolated Rabbit Hearts. Frontiers in physiology 2020. PMID: 32528304


  15. Lebert J, Christoph J. Synchronization-based reconstruction of electromechanical wave dynamics in elastic excitable media. Chaos (Woodbury, N.Y.) 2019. PMID: 31575136


  17. Christoph J, Chebbok M, Richter C, Schröder-Schetelig J, Bittihn P, Stein S, Uzelac I, Fenton FH, Hasenfuß G, Gilmour RF, Luther S. Electromechanical vortex filaments during cardiac fibrillation. Nature 2018. PMID: 29466325


  18. Christoph J, Schröder-Schetelig J, Luther S. Electromechanical optical mapping. Progress in biophysics and molecular biology 2017. PMID: 28947080


  19. Lilienkamp T, Christoph J, Parlitz U. Features of Chaotic Transients in Excitable Media Governed by Spiral and Scroll Waves. Physical review letters 2017. PMID: 28949756


  20. Richter C, Christoph J, Lehnart SE, Luther S. Optogenetic Light Crafting Tools for the Control of Cardiac Arrhythmias. Methods in molecular biology (Clifton, N.J.) 2016. PMID: 26965131