Ethan Weiss, MD

Assoc Prof In Res

Cardiology

CLINICAL INTERESTS: Dr. Ethan Weiss is a cardiologist specializing in general cardiology. His special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young.



RESEARCH INTERESTS: In his research, Dr. Weiss uses genetic models to better understand the mechanism of metabolic disorders such as obesity, fatty liver disease, and diabetes. He also studies the blood clotting system and has interest in identifying novel ways to safely block clots associated with diseases such as heart attack and stroke without causing an increase in bleeding.

Education
M.D., 1996 - School of Medicine, Johns Hopkins University
Clinical Fellowship, - School of Medicine - Cardiology, University of California, San Francisco
Websites
Publications

  1. Agrawal S, Luan J, Cummings BB, Weiss EJ, Wareham NJ, Khera AV. Relationship of Fat Mass Ratio, a Biomarker for Lipodystrophy, With Cardiometabolic Traits. Diabetes 2024. PMID: 38345889


  2. Nikkanen J, Leong YA, Krause WC, Dermadi D, Maschek JA, Van Ry T, Cox JE, Weiss EJ, Gokcumen O, Chawla A, Ingraham HA. An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice. Science (New York, N.Y.) 2022. PMID: 36264814


  3. Bennett JP, Liu YE, Quon BK, Kelly NN, Leong LT, Wong MC, Kennedy SF, Chow DC, Garber AK, Weiss EJ, Heymsfield SB, Shepherd JA. Three-dimensional optical body shape and features improve prediction of metabolic disease risk in a diverse sample of adults. Obesity (Silver Spring, Md.) 2022. PMID: 35894079


  4. Falkenhain K, Locke SR, Lowe DA, Lee T, Singer J, Weiss EJ, Little JP. Use of an mHealth Ketogenic Diet App Intervention and User Behaviors Associated With Weight Loss in Adults With Overweight or Obesity: Secondary Analysis of a Randomized Clinical Trial. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35285809


  5. Bennett JP, Liu YE, Quon BK, Kelly NN, Wong MC, Kennedy SF, Chow DC, Garber AK, Weiss EJ, Heymsfield SB, Shepherd JA. Assessment of clinical measures of total and regional body composition from a commercial 3-dimensional optical body scanner. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34915272


  6. Falkenhain K, Roach LA, McCreary S, McArthur E, Weiss EJ, Francois ME, Little JP. Effect of carbohydrate-restricted dietary interventions on LDL particle size and number in adults in the context of weight loss or weight maintenance: a systematic review and meta-analysis. The American journal of clinical nutrition 2021. PMID: 34159352


  7. Falkenhain K, Locke SR, Lowe DA, Reitsma NJ, Lee T, Singer J, Weiss EJ, Little JP. Keyto App and Device versus WW App on Weight Loss and Metabolic Risk in Adults with Overweight or Obesity: A Randomized Trial. Obesity (Silver Spring, Md.) 2021. PMID: 34124856


  8. Dylan Lowe, Kevin C. Corbit, Ethan J. Weiss. The Impact of Carbohydrate Restriction and Nutritional Ketosis on Cardiovascular Health. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID:


  9. Kaja Falkenhain, Sean Locke, Dylan Lowe, Nicholas Reitsma, Ethan Weiss, Jonathan Little. A Mediterranean-Based Ketogenic Diet Application Compared to a Calorie-Restricted Low-Fat Diet Application on Cardiometabolic Risk in Adults With Overweight or Obesity. Current Developments in Nutrition 2021. PMID:


  10. Weiss EJ, Lowe DA, Vittinghoff E. Caution Against Overinterpreting Time-Restricted Eating Results-Reply. JAMA internal medicine 2021. PMID: 33616599


  11. Moldavski O, Zushin PH, Berdan CA, Van Eijkeren RJ, Jiang X, Qian M, Ory DS, Covey DF, Nomura DK, Stahl A, Weiss EJ, Zoncu R. 4ß-hydroxycholesterol is a pro-lipogenic factor that promotes SREBP1c expression and activity through Liver X-receptor. Journal of lipid research 2021. PMID: 33631213


  12. Lowe DA, Wu N, Rohdin-Bibby L, Moore AH, Kelly N, Liu YE, Philip E, Vittinghoff E, Heymsfield SB, Olgin JE, Shepherd JA, Weiss EJ. Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity: The TREAT Randomized Clinical Trial. JAMA internal medicine 2020. PMID: 32986097


  13. Locke SR, Falkenhain K, Lowe DA, Lee T, Singer J, Weiss EJ, Little JP. Comparing the Keyto App and Device with Weight Watchers' WW App for Weight Loss: Protocol for a Randomized Trial. JMIR research protocols 2020. PMID: 32804087


  14. Chloe E Panizza, Michael C Wong, Nisa Kelly, Yong En Liu, Yurii B Shvetsov, Dylan A Lowe, Ethan J Weiss, Steven B Heymsfield, Samantha Kennedy, Carol J Boushey, Gertraud Maskarinec, John A Shepherd. Diet Quality and Visceral Adiposity Among a Multiethnic Population of Young, Middle and Older Aged Adults. Current Developments in Nutrition 2020. PMID:


  15. Panizza CE, Wong MC, Kelly N, Liu YE, Shvetsov YB, Lowe DA, Weiss EJ, Heymsfield SB, Kennedy S, Boushey CJ, Maskarinec G, Shepherd JA. Diet Quality and Visceral Adiposity among a Multiethnic Population of Young, Middle, and Older Aged Adults. Current Developments in Nutrition 2020. PMID: 33959689


  16. Dylan A Lowe, Ethan James Weiss, Jeffrey E Olgin, Eric Vittinghoff, John A Shepherd, Steven B Heymsfield, Linnea Rohdin-Bibby, Nisa Kelly, Nancy Wu. MON-LB107 Treat: A Randomized Controlled Trial Examining the Effects of Time Restricted Eating on Weight Loss and Metabolic Markers. Journal of the Endocrine Society 2020. PMID:


  17. Weiss EJ. Billy Idol. Perspectives in biology and medicine 2020. PMID: 32063587


  18. Corbit KC, Wilson CG, Lowe D, Tran JL, Vera NB, Clasquin M, Mattis AN, Weiss EJ. Adipocyte JAK2 mediates spontaneous metabolic liver disease and hepatocellular carcinoma. JCI insight 2019. PMID: 31393852


  19. Corbit KC, Camporez JPG, Edmunds LR, Tran JL, Vera NB, Erion DM, Deo RC, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ. Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. Volume 67 of Issue 2. 2017. PMID: 29203511


  20. Lee AP, Mulligan K, Schambelan M, Murphy EJ, Weiss EJ. Growth hormone receptor antagonism with pegvisomant in insulin resistant non-diabetic men: A phase II pilot study. Volume 6. 2017. PMID: 28713554


  21. Corbit KC, Camporez JP, Tran JL, Wilson CG, Lowe DA, Nordstrom SM, Ganeshan K, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ. Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance. Volume 2 of Issue 3. 2017. PMID: 28194444


  22. Wilson CG, Tran JL, Erion DM, Vera NB, Febbraio M, Weiss EJ. Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice. Volume 157 of Issue 2. 2015. PMID: 26650570


  23. Nordstrom SM, Tran JL, Sos BC, Wagner KU, Weiss EJ. Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH. Volume 27 of Issue 8. 2013. PMID: 23782652


  24. Hsue PY, Scherzer R, Grunfeld C, Nordstrom SM, Schnell A, Kohl LP, Nitta E, Martin JN, Deeks SG, Weiss EJ. HIV infection is associated with decreased thrombin generation. Volume 54 of Issue 8. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012. PMID: 22438347


  25. Nordstrom SM, Tran JL, Sos BC, Wagner KU, Weiss EJ. Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH. Volume 25 of Issue 7. 2011. PMID: 21527499


  26. Sos BC, Harris C, Nordstrom SM, Tran JL, Balázs M, Caplazi P, Febbraio M, Applegate MA, Wagner KU, Weiss EJ. Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2. Volume 121 of Issue 4. The Journal of clinical investigation 2011. PMID: 21364286


  27. Williams MS, Weiss EJ, Sabatine MS, Simon DI, Bahou WF, Becker LC, Parise LV, Dauerman HL, French PA, Smyth SS, Becker RC. Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development. Volume 30 of Issue 12. 2010. PMID: 21084706


  28. Nordstrom SM, Holliday BA, Sos BC, Smyth JW, Levy RE, Dukes JW, Lord ST, Weiss EJ. Increased thrombosis susceptibility and altered fibrin formation in STAT5-deficient mice. Volume 116 of Issue 25. Blood 2010. PMID: 20823455


  29. Katelyn M Dow, Sarah M Nordstrom, Brandon C Sos, Richard C Davis, Aldons J Lusis, Ethan J Weiss. A Novel Tissue Factor Resistance Locus on Mouse Chromosome 11 Confers Protection from Thrombosis through Reduced Activity of Factor XI. Blood 2008. PMID:


  30. Sarah M Nordstrom, Brandon C Sos, Katelyn M Dow, Tina S Fong, Robert E Levy, Jonathan Dukes, Ethan J Weiss. Increased Thrombosis in Vivo and Altered Coagulation in Vitro in STAT5AB-Deficient Mice. Blood 2008. PMID:


  31. Nordstrom SM, Weiss EJ. Sex differences in thrombosis. Volume 1 of Issue 1. 2008. PMID: 21083002


  32. Wong JH, Dukes J, Levy RE, Sos B, Mason SE, Fong TS, Weiss EJ. Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns. Volume 118 of Issue 8. The Journal of clinical investigation 2008. PMID: 18618017


  33. Joshua H. Wong, Robert E. Levy, Jonathan Dukes, Sara A. Mason, Brandon Sos, Ethan J. Weiss. Increased Thrombosis in Male Versus Female Mice Is Mediated by Pulsatile Growth Hormone Secretion Possibly through Inhibition of TFPI Expression in the Vasculature. Blood 2007. PMID:


  34. Weiss EJ, Hamilton JR, Lease KE, Coughlin SR. Protection against thrombosis in mice lacking PAR3. Blood 2002. PMID: 12384423


  35. Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin SR. Role of thrombin signalling in platelets in haemostasis and thrombosis. Nature 2001. PMID: 11544528


  36. Shapiro MJ, Weiss EJ, Faruqi TR, Coughlin SR. Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin. The Journal of biological chemistry 2000. PMID: 10837487


  37. Faruqi TR, Weiss EJ, Shapiro MJ, Huang W, Coughlin SR. Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function. The Journal of biological chemistry 2000. PMID: 10779527


  38. Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin SR. PAR3 is a cofactor for PAR4 activation by thrombin. Nature 2000. PMID: 10766244


  39. Goldschmidt-Clermont PJ, Coleman LD, Pham YM, Cooke GE, Shear WS, Weiss EJ, Kral BG, Moy TF, Yook RM, Blumenthal RS, Becker DM, Becker LC, Bray PF. Higher prevalence of GPIIIa PlA2 polymorphism in siblings of patients with premature coronary heart disease. Volume 123 of Issue 12. 1999. PMID: 10583927


  40. Bray PF, Weiss EJ, Tayback M, Goldschmidt-Clermont PJ. PlA1/A2 polymorphism of platelet glycoprotein IIIa and risk of cardiovascular disease. Volume 349 of Issue 9058. Lancet (London, England) 1997. PMID: 9107268


  41. Vandervoort J, Weiss EJ, Somnay K, Tham TC, Wong RC, Carr-Locke DL. Self-expanding metal stent for obstructing adenocarcinoma of the sigmoid. Volume 44 of Issue 6. 1996. PMID: 8979071


  42. Weiss EJ, Bray PF, Tayback M, Schulman SP, Kickler TS, Becker LC, Weiss JL, Gerstenblith G, Goldschmidt-Clermont PJ. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. Volume 334 of Issue 17. The New England journal of medicine 1996. PMID: 8598867


  43. Weiss EJ, Goldschmidt-Clermont PJ, Grigoryev D, Jin Y, Kickler TS, Bray PF. A monoclonal antibody (SZ21) specific for platelet GPIIIa distinguishes P1A1 from P1A2. Volume 46 of Issue 5. 1995. PMID: 8838346