Elias Botvinick, MD

Education
M.D., 1967 - School of Medicine, New York University
Clinical Fellowship, - School of Medicine, University of California, San Francisco
Residency, - School of Medicine - Cardiology, University of California, San Francisco
Honors and Awards
  • Best Doctor's in California, Cardiology & Nuclear Medicine, San Francisco Magazine, 2000
  • Founding Member ASNC, American Society of Nuclear Cardiology, 1998
  • Keynote Speaker, Graduation Nuclear Medicine Technology Training Program, 1994
  • Founder and First President of the Cardiovascular Council, Society of Nuclear Medicine, 1992
  • Recipient Herman H. Blumgart Lectureship Award, Society of Nuclear Medicine, 1991
  • Bronze Star Medal Award, Republic of Vietnam, United States Army, 1971
  • Nominated for UCSF Medical School Kaiser award for Excellence in Teaching, University of California, San Francisco School of Medicine
Websites
Publications

  1. Shrestha UM, Sciammarella M, Pampaloni MH, Botvinick EH, Gullberg GT, DeMarco T, Seo Y. Assessment of late-term progression of cardiac allograft vasculopathy in patients with orthotopic heart transplantation using quantitative cardiac 82Rb PET. The international journal of cardiovascular imaging 2020. PMID: 33123937


  2. Botvinick EH. The beginnings of ASNC. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2018. PMID: 30478663


  3. Mitra D, Abdalah M, Boutchko R, Chang H, Shrestha U, Botvinick E, Seo Y, Gullberg GT. Comparison of sparse domain approaches for 4D SPECT dynamic image reconstruction. Medical physics 2018. PMID: 30027577


  4. Sciammarella M, Shrestha UM, Seo Y, Gullberg GT, Botvinick EH. A combined static-dynamic single-dose imaging protocol to compare quantitative dynamic SPECT with static conventional SPECT. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2017. PMID: 28776314


  5. Pampaloni MH, Shrestha UM, Sciammarella M, Seo Y, Gullberg GT, Botvinick EH. Noninvasive PET quantitative myocardial blood flow with regadenoson for assessing cardiac allograft vasculopathy in orthotopic heart transplantation patients. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2017. PMID: 28138813


  6. Badhwar N, James J, Hoffmayer KS, O'Connell JW, Green D, De Marco T, Botvinick EH. Utility of Equilibrium Radionuclide Angiogram-Derived Measures of Dyssynchrony to Predict Outcomes in Heart Failure Patients Undergoing Cardiac Resynchronization Therapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2016. PMID: 27417646


  7. Shrestha U, Sciammarella M, Alhassen F, Yeghiazarians Y, Ellin J, Verdin E, Boyle A, Seo Y, Botvinick EH, Gullberg GT. Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99mTc-tetrofosmin: Method and validation. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2015. PMID: 26715603


  8. Shrestha UM, Seo Y, Botvinick EH, Gullberg GT. Image reconstruction in higher dimensions: myocardial perfusion imaging of tracer dynamics with cardiac motion due to deformation and respiration. Physics in medicine and biology 2015. PMID: 26450115


  9. Johnson CJ, Roberts JD, James JH, Hoffmayer KS, Badhwar N, Ku IA, Zhao S, Naeger DM, Rao RK, O'Connell JW, De Marco T, Botvinick EH, Scheinman MM. Comparison of radionuclide angiographic synchrony analysis to echocardiography and magnetic resonance imaging for the diagnosis of arrhythmogenic right ventricular cardiomyopathy. Heart rhythm 2015. PMID: 25744613


  10. Pampaloni MH, Nazer B, Botvinick E. Erratum to: Isolated right ventricular cardiac sarcoidosis demonstrated by (18)FDG positron emission tomography. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2015. PMID: 25342216


  11. Shrestha U, Botvinick EH, Yeghiazarians Y, Seo Y, Gullberg GT. Quantitative Signature of Coronary Steal in a Patient with Occluded Coronary Arteries Supported by Collateral Circulation Using Dynamic SPECT. IEEE Nuclear Science Symposium conference record. Nuclear Science Symposium 2014. PMID: 27081301


  12. Hernandez Pampaloni M, Nazer B, Nazar B, Botvinick E. Isolated right ventricular cardiac sarcoidosis demonstrated by ¹8FDG positron emission tomography. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2014. PMID: 24429936


  13. Botvinick EH, O'Connell JW, Badhwar N. Imaging synchrony. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2009. PMID: 19798545


  14. del Romeral LM, Stillson C, Lesh M, Botvinick E. The variable functional effects of the pacing site in normal and scarred ventricles. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2009. PMID: 19760474


  15. del Romeral LM, Stillson C, Lesh M, Dae M, Botvinick E. The relationship of myocardial contraction and electrical excitation--the correlation between scintigraphic phase image analysis and electrophysiologic mapping. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2009. PMID: 19636652


  16. Bural GG, Torigian DA, Botvinick E, Houseni M, Basu S, Chen W, Alavi A. A pilot study of changes in (18)F-FDG uptake, calcification and global metabolic activity of the aorta with aging. Hellenic journal of nuclear medicine 2009. PMID: 19675864


  17. Botvinick EH. Current methods of pharmacologic stress testing and the potential advantages of new agents. Journal of nuclear medicine technology 2009. PMID: 19258260


  18. Botvinick E, Davis J, Dae M, O'Connell J, Schechtmann N, Abbott J, Morady F, Lanzer P, Iskikian J, Scheinman M. Localization of ventricular tachycardia exit site and subsequent contraction sequence and functional effects with bedside radionuclide angiography. JACC. Cardiovascular imaging 2008. PMID: 19356489


  19. Chen W, Botvinick EH, Alavi A, Zhang Y, Yang S, Perini R, Zhuang H. Age-related decrease in cardiopulmonary adrenergic neuronal function in children as assessed by I-123 metaiodobenzylguanidine imaging. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2008. PMID: 18242482


  20. Hansen CL, Goldstein RA, Akinboboye OO, Berman DS, Botvinick EH, Churchwell KB, Cooke CD, Corbett JR, Cullom SJ, Dahlberg ST, Druz RS, Ficaro EP, Galt JR, Garg RK, Germano G, Heller GV, Henzlova MJ, Hyun MC, Johnson LL, Mann A, McCallister BD, Quaife RA, Ruddy TD, Sundaram SN, Taillefer R, Ward RP, Mahmarian JJ. Myocardial perfusion and function: single photon emission computed tomography. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2007. PMID: 18022099


  21. Botvinick EH, Perini R, Bural G, Chen W, Chryssikos T, Houseni M, Hernandez-Pampaloni M, Torigian DA, Alavi A. The aging of the heart and blood vessels: a consideration of anatomy and physiology in the era of computed tomography, magnetic resonance imaging, and positron emission tomographic imaging methods with special consideration of atherogenesis. Seminars in nuclear medicine 2007. PMID: 17289459


  22. Corbett JR, Akinboboye OO, Bacharach SL, Borer JS, Botvinick EH, DePuey EG, Ficaro EP, Hansen CL, Henzlova MJ, Van Kriekinge S. Equilibrium radionuclide angiocardiography. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2006. PMID: 17174797


  23. Funk T, Kirch DL, Koss JE, Botvinick E, Hasegawa BH. A novel approach to multipinhole SPECT for myocardial perfusion imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006. PMID: 16595492


  24. O'Connell JW, Schreck C, Moles M, Badwar N, DeMarco T, Olgin J, Lee B, Tseng Z, Kumar U, Botvinick EH. A unique method by which to quantitate synchrony with equilibrium radionuclide angiography. Volume 12 of Issue 4. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2005. PMID: 16084433


  25. Heller GV, Bateman TM, Johnson LL, Cullom SJ, Case JA, Galt JR, Garcia EV, Haddock K, Moutray KL, Poston C, Botvinick EH, Fish MB, Follansbee WP, Hayes S, Iskandrian AE, Mahmarian JJ, Vandecker W. Clinical value of attenuation correction in stress-only Tc-99m sestamibi SPECT imaging. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2004. PMID: 15173774


  26. Pham KH, Botvinick EH. Increased right ventricular activity: artifact of camera head misalignment. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2003. PMID: 14569251


  27. Botvinick EH. Scintigraphic blood pool and phase image analysis: the optimal tool for the evaluation of resynchronization therapy. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2003. PMID: 12900747


  28. Yun JH, Block M, Botvinick EH. Unique contraction pattern in patients after coronary bypass graft surgery by gated SPECT myocardial perfusion imaging. Clinical nuclear medicine 2003. PMID: 12493955


  29. Allman KC, Godoy I, Olea E, Lekakis J, Zafir N, Metcalfe M, Prigent F, Botvinick EH, Hendrix GH. Current practice. The role of noninvasive testing and affect of VANQWISH/FRISC II trials on managing acute coronary syndrome patients. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2001. PMID: 11642262


  30. Brown JK, Tang HR, Hattner RS, Bocher M, Ratzlaff NW, Kadkade PP, Hasegawa BH, Botvinick EH. Intrinsic dual-energy processing of myocardial perfusion images. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2000. PMID: 10914923


  31. Redberg RF, Nishino M, McElhinney DB, Dae MW, Botvinick EH. Long-term estrogen replacement therapy is associated with improved exercise capacity in postmenopausal women without known coronary artery disease. Volume 139 of Issue 4. American heart journal 2000. PMID: 10740161


  32. Kerwin WF, Botvinick EH, O'Connell JW, Merrick SH, DeMarco T, Chatterjee K, Scheibly K, Saxon LA. Ventricular contraction abnormalities in dilated cardiomyopathy: effect of biventricular pacing to correct interventricular dyssynchrony. Journal of the American College of Cardiology 2000. PMID: 10758964


  33. Challa S, Botvinick EH, Neymark E, Price D, Hawkins RA. An unusual presentation of non-Hodgkin's lymphoma: a case report. Clinical nuclear medicine 2000. PMID: 10656660


  34. Oka RK, De Marco T, Haskell WL, Botvinick E, Dae MW, Bolen K, Chatterjee K. Impact of a home-based walking and resistance training program on quality of life in patients with heart failure. The American journal of cardiology 2000. PMID: 11078308


  35. Barron HV, Sciammarella MG, Lenihan K, Michaels AD, Botvinick EH. Effects of the repeated administration of adenosine and heparin on myocardial perfusion in patients with chronic stable angina pectoris. The American journal of cardiology 2000. PMID: 11078227


  36. Bobba K, Botvinick EH, Sciammarella MG, Starsken NF, Zhu YY, Lapidus A, Dae MW. Is there any advantage to the acquisition of 24-hour thallium images, in the presence of persistent perfusion defects at 4 h after reinjection? European journal of nuclear medicine 1998. PMID: 9575247


  37. Botvinick EH, O'Connell JW, Kadkade PP, Glickman SL, Dae MW, Cohen TJ, Abbott J, Krishnan R. Potential added value of three-dimensional reconstruction and display of single photon emission computed tomographic gated blood pool images. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 1998. PMID: 9669579


  38. DePuey EG, Port S, Wackers FJ, Rozanski A, Botvinick EH, Dae MW, Tamaki N. Nonperfusion applications in nuclear cardiology: report of a task force of the American Society of Nuclear Cardiology. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 1998. PMID: 9588675


  39. Segall GM, Stepp C, Kadkade PP, Dae MW, Botvinick EH. Fast acquisition of myocardial SPECT images with Tc-99m sestamibi for the diagnosis of coronary artery disease. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 1997. PMID: 9362011


  40. Huesman RH, Klein GJ, Reutter BW, Coxson PG, Botvinick EH, Budinger TF. Strategies for extraction of quantitative data from volumetric dynamic cardiac positron emission tomography data. Cardiology 1997. PMID: 8960627


  41. Chou TM, Sudhir K, Amidon TM, Klinski CS, DeMarco T, Chatterjee K, Botvinick EH. Comparison of adenosine to dipyridamole in degree of coronary hyperemic response in heart transplant recipients. The American journal of cardiology 1996. PMID: 8888664


  42. Hendel RC, Verani MS, Miller DD, Wackers FJ, McMahon M, Cerqueira MD, Botvinick EH, Kvols L, Gerson MC. Diagnostic utility of tomographic myocardial perfusion imaging with technetium 99m furifosmin (Q12) compared with thallium 201: results of a phase III multicenter trial. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 1996. PMID: 8799247


  43. Knollmann FD, Mäurer J, Kücherer H, Böck JC, O'Connell JW, Botvinick E, Eichstädt HW, Felix R. Cardiac activation mapping by MRI. Magma (New York, N.Y.) 1996. PMID: 8773998


  45. Dae MW, O'Connell JW, Botvinick EH, Chin MC. Acute and chronic effects of transient myocardial ischemia on sympathetic nerve activity, density, and norepinephrine content. Cardiovascular research 1995. PMID: 7585815


  47. Segall GM, Atwood JE, Botvinick EH, Dae MW, Lucas JR. Variability of normal coronary anatomy: implications for the interpretation of thallium-SPECT myocardial perfusion images in single-vessel disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995. PMID: 7769450


  48. Foster E, O'Kelly B, LaPidus A, Sandler D, Tucker K, Dae M, Schiller NB, Botvinick EH. Segmental analysis of resting echocardiographic function and stress scintigraphic perfusion: implications for myocardial viability. American heart journal 1995. PMID: 7817927


  49. Botvinick EH. A consideration of current clinical options for stress imaging in the diagnosis and evaluation of coronary artery disease. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 1994. PMID: 9420740


  50. Lee MA, Dae MW, Langberg JJ, Griffin JC, Chin MC, Finkbeiner WE, O'Connell JW, Botvinick E, Scheinman MM, Rosenqvist M. Effects of long-term right ventricular apical pacing on left ventricular perfusion, innervation, function and histology. Journal of the American College of Cardiology 1994. PMID: 8006270


  53. Newman D, Munoz L, Chin M, Franz M, Herre J, Scheinman MM, Botvinick E, Dae M. Effects of canine myocardial infarction on sympathetic efferent neuronal function: scintigraphic and electrophysiologic correlates. American heart journal 1993. PMID: 8237752


  54. Botvinick EH, Dae MW, Krishnan R, Ewing S. Hypertrophic cardiomyopathy in the young: another form of ischemic cardiomyopathy? Journal of the American College of Cardiology 1993. PMID: 8354815


  55. Krishnan R, Lu J, Zhu YY, Dae MW, Botvinick EH. Myocardial perfusion scintigraphy in left bundle branch block: a perspective on the issue from image analysis in a clinical context. American heart journal 1993. PMID: 8362712


  56. Lucas JR, Botvinick EH, Dae MW. Myocardial viability: evidence provided by the analysis of left ventricular systolic function. Coronary artery disease 1993. PMID: 8261226


  57. Botvinick EH. The proper tool for the job. Journal of the American College of Cardiology 1993. PMID: 8473637


  58. Starksen NF, O'Connell W, Dae MW, Botvinick EH. Basal interventricular septal thallium-201 defects: real or artifact? Clinical nuclear medicine 1993. PMID: 8482025


  59. Botvinick EH, Zhu YY, O'Connell WJ, Dae MW. A quantitative assessment of patient motion and its effect on myocardial perfusion SPECT images. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1993. PMID: 8429354


  60. Munoz del Romeral L, Dae MW, Ports TA, Botvinick EH. Diagnostic and prognostic value of ambulatory electrocardiographic monitoring. American heart journal 1992. PMID: 1442488


  61. Dae MW, De Marco T, Botvinick EH, O'Connell JW, Hattner RS, Huberty JP, Yuen-Green MS. Scintigraphic assessment of MIBG uptake in globally denervated human and canine hearts--implications for clinical studies. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1992. PMID: 1634934


  62. Cohen TJ, Tucker KJ, Abbott JA, Botvinick EH, Foster E, Schiller NB, O'Connell JW, Scheinman MM. Usefulness of adenosine in augmenting ventricular preexcitation for noninvasive localization of accessory pathways. The American journal of cardiology 1992. PMID: 1575188


  63. Tucker KJ, Cohen TJ, Botvinick EH, Schiller NB. The applications of adenosine in noninvasive cardiac imaging. Herz 1992. PMID: 1577364


  64. Botvinick EH. Advances in myocardial scintigraphy in coronary heart disease. American journal of cardiac imaging 1992. PMID: 10147611


  65. Kuecherer HF, Abbott JA, Botvinick EH, Scheinman ED, O'Connell JW, Scheinman MM, Foster E, Schiller NB. Two-dimensional echocardiographic phase analysis. Its potential for noninvasive localization of accessory pathways in patients with Wolff-Parkinson-White syndrome. Circulation 1992. PMID: 1728442


  66. Watters TA, Botvinick EH, Dae MW, Cahalan M, Urbanowicz J, Benefiel DJ, Schiller NB, Goldstone G, Reilly L, Stoney RJ. Comparison of the findings on preoperative dipyridamole perfusion scintigraphy and intraoperative transesophageal echocardiography: implications regarding the identification of myocardium at ischemic risk. Journal of the American College of Cardiology 1991. PMID: 2050947


  67. Botvinick EH, Dae MW. Dipyridamole perfusion scintigraphy. Seminars in nuclear medicine 1991. PMID: 1948114


  68. Oeff M, Scheinman MM, Abbott JA, Botvinick EH, Griffin JC, Herre JM, Dae MW. Phase image triangulation of accessory pathways in patients undergoing catheter ablation of posteroseptal pathways. Pacing and clinical electrophysiology : PACE 1991. PMID: 1715068


  69. Dae MW, Herre JM, O'Connell JW, Botvinick EH, Newman D, Munoz L. Scintigraphic assessment of sympathetic innervation after transmural versus nontransmural myocardial infarction. Journal of the American College of Cardiology 1991. PMID: 2016460


  70. Rosenqvist M, Isaaz K, Botvinick EH, Dae MW, Cockrell J, Abbott JA, Schiller NB, Griffin JC. Relative importance of activation sequence compared to atrioventricular synchrony in left ventricular function. The American journal of cardiology 1991. PMID: 1987716


  71. Zhu YY, Chung WS, Botvinick EH, Dae MW, Lim AD, Ports TA, Danforth JW, Wolfe CL, Goldschlager N, Chatterjee K. Dipyridamole perfusion scintigraphy: the experience with its application in one hundred seventy patients with known or suspected unstable angina. American heart journal 1991. PMID: 1985375


  72. Botvinick EH. The promise of technetium-99m-based perfusion imaging agents. Circulation 1990. PMID: 2132557


  73. Landzberg JS, Franklin JO, Mahawar SK, Himelman RB, Botvinick EH, Schiller NB, Springer MJ, Griffin JC. Benefits of physiologic atrioventricular synchronization for pacing with an exercise rate response. The American journal of cardiology 1990. PMID: 2371950


  74. Dae MW, Botvinick EH. Imaging of the heart using metaiodobenzylguanidine. Journal of thoracic imaging 1990. PMID: 2194039


  75. Urbanowicz JH, Shaaban MJ, Cohen NH, Cahalan MK, Botvinick EH, Chatterjee K, Schiller NB, Dae MW, Matthay MA. Comparison of transesophageal echocardiographic and scintigraphic estimates of left ventricular end-diastolic volume index and ejection fraction in patients following coronary artery bypass grafting. Anesthesiology 1990. PMID: 2321775


  76. Botvinick EH. "Hot spot" imaging agents for acute myocardial infarction. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1990. PMID: 2179484


  77. Gober JR, Schaefer S, Camacho SA, DeGroot M, Obregon R, Botvinick EH, Weiner M, Massie B. Epicardial and endocardial localized 31P magnetic resonance spectroscopy: evidence for metabolic heterogeneity during regional ischemia. Magnetic resonance in medicine 1990. PMID: 2314211


  78. Botvinick EH. Late reversibility: a viability issue. Journal of the American College of Cardiology 1990. PMID: 2299074


  79. Hylton NM, Chung WS, Botvinick EH, Schiller NB, Sheldon P, Kaufman L. Oblique reformatting of multislice magnetic resonance images for improved visualization of coronary arteries. Journal of digital imaging 1990. PMID: 2092801


  80. Botvinick EH, Dae MW, O'Connell JW. Blood pool scintigraphy. Cardiology clinics 1989. PMID: 2670226


  81. Bouchard A, Sanz N, Botvinick EH, Phillips N, Heilbron D, Byrd BF, Karam JH, Schiller NB. Noninvasive assessment of cardiomyopathy in normotensive diabetic patients between 20 and 50 years old. The American journal of medicine 1989. PMID: 2757056


  82. Schaefer S, Camacho SA, Gober J, Obregon RG, DeGroot MA, Botvinick EH, Massie B, Weiner MW. Response of myocardial metabolites to graded regional ischemia: 31P NMR spectroscopy of porcine myocardium in vivo. Circulation research 1989. PMID: 2706762


  83. Bouchard A, Yock P, Schiller NB, Blumlein S, Botvinick EH, Greenberg B, Cheitlin M, Massie BM. Value of color Doppler estimation of regurgitant volume in patients with chronic aortic insufficiency. American heart journal 1989. PMID: 2711970


  84. Dae M, Wen YM, Botvinick EH, Scheinman M. ECG left anterior fascicular block reveals diverse patterns on scintigraphic phase analysis. American heart journal 1989. PMID: 2929402


  85. Schechtmann N, Botvinick EH, Dae M, Scheinman MM, O'Connell JW, Davis J, Winston S, Schwartz A, Abbott J. The scintigraphic characteristics of ventricular pre-excitation through Mahaim fibers with the use of phase analysis. Journal of the American College of Cardiology 1989. PMID: 2494242


  86. Dae MW, O'Connell JW, Botvinick EH, Ahearn T, Yee E, Huberty JP, Mori H, Chin MC, Hattner RS, Herre JM. Scintigraphic assessment of regional cardiac adrenergic innervation. Circulation 1989. PMID: 2783894


  87. Schaefer S, Gober J, Valenza M, Karczmar GS, Matson GB, Camacho SA, Botvinick EH, Massie B, Weiner MW. Nuclear magnetic resonance imaging-guided phosphorus-31 spectroscopy of the human heart. Journal of the American College of Cardiology 1988. PMID: 3192842


  89. Botvinick EH. Breast attenuation artifacts in Tl-201 scintigraphy. Radiology 1988. PMID: 3406418


  90. Camacho SA, Lanzer P, Toy BJ, Gober J, Valenza M, Botvinick EH, Weiner MW. In vivo alterations of high-energy phosphates and intracellular pH during reversible ischemia in pigs: a 31P magnetic resonance spectroscopy study. American heart journal 1988. PMID: 3414485


  91. Zhu YY, Botvinick E, Dae M, Golden J, Hattner R, Scheinman M. Gallium lung scintigraphy in amiodarone pulmonary toxicity. Chest 1988. PMID: 3371091


  92. Botvinick EH, Dae M. Dipyridamole myocardial perfusion scintigraphy. The Western journal of medicine 1988. PMID: 18750408


  93. White RD, Holt WW, Cheitlin MD, Cassidy MM, Ports TA, Lim AD, Botvinick EH, Higgins CB. Estimation of the functional and anatomic extent of myocardial infarction using magnetic resonance imaging. American heart journal 1988. PMID: 3354402


  94. Botvinick EH, O'Connell WJ, Dae MW, Hattner RS, Schechtmann NM. Analysis of thallium-201 "washout" from parametric color coded images. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1988. PMID: 3346740


  95. Camacho SA, Wikman-Coffelt J, Wu ST, Watters TA, Botvinick EH, Sievers R, James TL, Jasmin G, Parmley WW. Improvement in myocardial performance without a decrease in high-energy phosphate metabolites after isoproterenol in Syrian cardiomyopathic hamsters. Circulation 1988. PMID: 3342496


  96. Camacho SA, Parmley WW, James TL, Abe H, Wu ST, Botvinick EH, Watters TA, Schiller N, Sievers R, Wikman-Coffelt J. Substrate regulation of the nucleotide pool during regional ischaemia and reperfusion in an isolated rat heart preparation: a phosphorus-31 magnetic resonance spectroscopy analysis. Cardiovascular research 1988. PMID: 3167943


  97. Watters TA, Botvinick E, Parmley WW, Wu S, Wikman-Coffelt J. Chemomechanics of altered perfusion pressure in rat hearts. Basic research in cardiology 1988. PMID: 3377741


  98. Garrett JS, Jaschke W, Aherne T, Botvinick EH, Higgins CB, Lipton MJ. Quantitation of intracardiac shunts by cine-CT. Journal of computer assisted tomography 1988. PMID: 3275697


  99. White RD, Cassidy MM, Cheitlin MD, Emilson B, Ports TA, Lim AD, Botvinick EH, Schiller NB, Higgins CB. Segmental evaluation of left ventricular wall motion after myocardial infarction: magnetic resonance imaging versus echocardiography. American heart journal 1988. PMID: 3336970


  100. Watters TA, Wendland MF, Parmley WW, James TL, Botvinick EH, Wu ST, Sievers R, Wikman-Coffelt J. Factors influencing myocardial response to metabolic acidosis in isolated rat hearts. The American journal of physiology 1987. PMID: 3688265


  101. Botvinick E, Schechtmann N, Dae M, Scheinman M, Davis J, Herre J, Iskikian T, Abbott J. Augmented preexcitation assessed by scintigraphic phase analysis during atrial pacing. American heart journal 1987. PMID: 3661363


  102. Bouchard A, Watters TA, Wu S, Parmley WW, Stone RD, Botvinick E, Sievers R, Jasmin G, Wikman-Coffelt J. Effects of altered coronary perfusion pressure on function and metabolism of normal and cardiomyopathic hamster hearts. Journal of molecular and cellular cardiology 1987. PMID: 3437452


  103. Axelrod RJ, De Marco T, Dae M, Botvinick EH, Chatterjee K. Hemodynamic and clinical evaluation of piroximone, a new inotrope-vasodilator agent, in severe congestive heart failure. Journal of the American College of Cardiology 1987. PMID: 3571752


  104. Cahalan MK, Litt L, Botvinick EH, Schiller NB. Advances in noninvasive cardiovascular imaging: implications for the anesthesiologist. Anesthesiology 1987. PMID: 3548487


  105. Mickelson JK, Byrd BF, Bouchard A, Botvinick EH, Schiller NB. Left ventricular dimensions and mechanics in distance runners. American heart journal 1986. PMID: 3788772


  106. Lanzer P, Garrett J, Lipton MJ, Gould R, Sievers R, O'Connell W, Botvinick E, Higgins CB. Quantitation of regional myocardial function by cine computed tomography: pharmacologic changes in wall thickness. Journal of the American College of Cardiology 1986. PMID: 3745717


  107. Blumlein S, Bouchard A, Schiller NB, Dae M, Byrd BF, Ports T, Botvinick EH. Quantitation of mitral regurgitation by Doppler echocardiography. Circulation 1986. PMID: 3731421


  108. Garrett JS, Schiller NB, Botvinick EH, Higgins CB, Lipton MJ. Cine-computed tomography of Ebstein anomaly. Journal of computer assisted tomography 1986. PMID: 3734206


  109. Hansen RM, Viquerat CE, Matthay MA, Wiener-Kronish JP, DeMarco T, Bahtia S, Marks JD, Botvinick EH, Chatterjee K. Poor correlation between pulmonary arterial wedge pressure and left ventricular end-diastolic volume after coronary artery bypass graft surgery. Anesthesiology 1986. PMID: 3487261


  110. McNamara MT, Tscholakoff D, Revel D, Soulen R, Schechtmann N, Botvinick E, Higgins CB. Differentiation of reversible and irreversible myocardial injury by MR imaging with and without gadolinium-DTPA. Radiology 1986. PMID: 3945751


  111. Schiller NB, Botvinick EH. Noninvasive quantitation of the left heart by echocardiography and scintigraphy. Cardiovascular clinics 1986. PMID: 3490309


  112. Lanzer P, Dean PB, Lipton MJ, Sievers R, Botvinick E, Higgins CB. Effects of intravenous administration of a new nonionic dimeric contrast medium on the coronary circulation. Comparison with monomeric ionic and nonionic media. Investigative radiology 1985. PMID: 4066245


  113. Garrett JS, Lanzer P, Jaschke W, Botvinick E, Sievers R, Higgins CB, Lipton MJ. Measurement of cardiac output by cine computed tomography. The American journal of cardiology 1985. PMID: 3901722


  114. Canhasi B, Dae M, Botvinick E, Lanzer P, Schechtmann N, Faulkner D, O'Connell W, Schiller N. Interaction of "supplementary" scintigraphic indicators of ischemia and stress electrocardiography in the diagnosis of multivessel coronary disease. Journal of the American College of Cardiology 1985. PMID: 4031268


  115. Wahr DW, Ports TA, Botvinick EH, Dae M, Schechtmann N, Huberty J, Hattner RS, O'Connell JW, Turley K. The effects of coronary angioplasty and reperfusion on distribution of myocardial flow. Circulation 1985. PMID: 3159510


  116. Viquerat CE, Hansen RM, Botvinick EH, Dae MW, Wiener-Kronish JP, Matthay MA. Undrained bloody pericardial effusion in the early postoperative period after coronary bypass surgery: a prospective blood pool study. American heart journal 1985. PMID: 3875274


  117. Lanzer PA, Botvinick EH, Higgins CB. [Imaging of the heart using nuclear magnetic resonance tomography. I: Tomography]. Zeitschrift fur Kardiologie 1985. PMID: 4049993


  118. Dae M, Canhasi B, Botvinick E, Olvera S, Schechtmann N, Engelstad B, Hattner R, Schiller N, O'Connell W, Faulkner D. The etiology and implications of dense cavitary "photopenia" on myocardial perfusion scintigraphy. Investigative radiology 1985. PMID: 4044180


  119. Lanzer P, Barta C, Botvinick EH, Wiesendanger HU, Modin G, Higgins CB. ECG-synchronized cardiac MR imaging: method and evaluation. Radiology 1985. PMID: 4001369


  120. Higgins CB, Byrd BF, McNamara MT, Lanzer P, Lipton MJ, Botvinick E, Schiller NB, Crooks LE, Kaufman L. Magnetic resonance imaging of the heart: a review of the experience in 172 subjects. Radiology 1985. PMID: 3159039


  121. Byrd BF, Schiller NB, Botvinick EH, Higgins CB. Normal cardiac dimensions by magnetic resonance imaging. The American journal of cardiology 1985. PMID: 3993592


  122. Higgins CB, Byrd BF, Stark D, McNamara M, Lanzer P, Lipton MJ, Schiller NB, Botvinick E, Chatterjee K. Magnetic resonance imaging in hypertrophic cardiomyopathy. The American journal of cardiology 1985. PMID: 4039104


  123. McNamara MT, Higgins CB, Schechtmann N, Botvinick E, Lipton MJ, Chatterjee K, Amparo EG. Detection and characterization of acute myocardial infarction in man with use of gated magnetic resonance. Circulation 1985. PMID: 3971541


  124. Wen YM, Botvinick EH. [Diagnosis of left bundle branch block with the phase analysis of radionuclide images]. Zhonghua xin xue guan bing za zhi 1985. PMID: 4006700


  125. Wen YM, Botvinick EH, Sheinman MM. Assessment of left intraventricular block by scintigraphic analysis. Chinese medical journal 1985. PMID: 3922692


  126. Higgins CB, Lanzer P, Stark D, Botvinick E, Schiller NB, Lipton MJ, Crooks LE, Kaufman L. Assessment of cardiac anatomy using nuclear magnetic resonance imaging. Journal of the American College of Cardiology 1985. PMID: 3965536


  127. Lallemand D, Wesbey GE, Gooding CA, Ehman R, Brasch RC, Ortendahl D, McNamara MT, Lanzer P, Botvinick E, Crooks E. Cardiosynchronous MRI intensity changes of the great vessels and pulmonary circulation. A preliminary report. Annales de radiologie 1985. PMID: 4014981


  128. Lallemand D, Gooding CA, Wesbey GE, Brasch RC, Botvinick E, Lanzer P, McNamara MT. Magnetic resonance (MR) imaging of aorta and pulmonary circulation. Initial experience with ECG-gating. Annales de radiologie 1985. PMID: 4014980


  129. Crooks LE, Barker B, Chang H, Feinberg D, Hoenninger JC, Watts JC, Arakawa M, Kaufman L, Sheldon PE, Botvinick E. Magnetic resonance imaging strategies for heart studies. Radiology 1984. PMID: 6484178


  130. Kereiakes DJ, Viquerat C, Lanzer P, Botvinick EH, Spangenberg R, Buckingham M, Parmley WW, Chatterjee K. Mechanisms of improved left ventricular function following intravenous MDL 17,043 in patients with severe chronic heart failure. American heart journal 1984. PMID: 6238512


  131. Frais M, Botvinick E, Shosa D, O'Connell W, Pacheco Alvarez J, Dae M, Hattner R, Faulkner D. Phase image characterization of localized and generalized left ventricular contraction abnormalities. Journal of the American College of Cardiology 1984. PMID: 6491089


  132. Botvinick EH. The scintigraphic identification of "severe myocardial ischemia". Giornale italiano di cardiologia 1984. PMID: 6526207


  133. DiCarlo LA, Botvinick EH, Canhasi BS, Schwartz AS, Chatterjee K. Value of noninvasive assessment of patients with atypical chest pain and suspected coronary spasm using ergonovine infusion and thallium-201 scintigraphy. The American journal of cardiology 1984. PMID: 6486023


  134. Bhandari A, Morady F, Shen EN, Schwartz AB, Botvinick E, Scheinman MM. Catheter-induced His bundle ablation in a patient with reentrant tachycardia associated with a nodoventricular tract. Journal of the American College of Cardiology 1984. PMID: 6470343


  135. Kereiakes DJ, Ports TA, Botvinick EH, Schiller NB, Turley K, Chatterjee K. Right ventricular myocardial infarction with ventricular septal rupture. American heart journal 1984. PMID: 6720553


  136. Brundage BH, Massie BM, Botvinick EH. Improved regional ventricular function after successful surgical revascularization. Journal of the American College of Cardiology 1984. PMID: 6608546


  137. Higgins CB, Lanzer P, Stark D, Botvinick E, Schiller NB, Crooks L, Kaufman L, Lipton MJ. Imaging by nuclear magnetic resonance in patients with chronic ischemic heart disease. Circulation 1984. PMID: 6692514


  138. Botvinick E, Frais M, O'Connell W, Faulkner D, Scheinman M, Morady F, Sung R, Shosa D, Dae M. Phase image evaluation of patients with ventricular pre-excitation syndromes. Journal of the American College of Cardiology 1984. PMID: 6693651


  139. Dae MW, Botvinick EH. Characterization of conduction and concentration abnormalities by scintigraphic phase analysis. International journal of cardiology 1984. PMID: 6698652


  140. Lanzer P, Botvinick EH, Schiller NB, Crooks LE, Arakawa M, Kaufman L, Davis PL, Herfkens R, Lipton MJ, Higgins CB. Cardiac imaging using gated magnetic resonance. Radiology 1984. PMID: 6227934


  141. Wesbey G, Higgins CB, Lanzer P, Botvinick E, Lipton MJ. Imaging and characterization of acute myocardial infarction in vivo by gated nuclear magnetic resonance. Circulation 1984. PMID: 6689636


  142. Misbach GA, Botvinick EH, Tyberg JV, Parmley WW, Dunn RF, Frais M. The functional implications of scintigraphic measures of myocardial ischemia and infarction. American heart journal 1983. PMID: 6637783


  143. Hlatky MA, Lee KL, Botvinick EH, Brundage BH. Diagnostic test use in different practice settings. A controlled comparison. Archives of internal medicine 1983. PMID: 6625773


  144. Engelstad BL, Wagner S, Herfkens R, Botvinick E, Brundage B, Lipton M. Evaluation of the post-coronary artery bypass patient by myocardial perfusion scintigraphy and computed tomography. AJR. American journal of roentgenology 1983. PMID: 6603759


  145. Higgins CB, Botvinick EH, Lanzer P, Herfkens R, Lipton MJ, Crooks LE, Kaufman L. Cardiovascular imaging with nuclear magnetic resonance. Cardiology clinics 1983. PMID: 6544138


  146. Goldstein JA, Vlahakes GJ, Verrier ED, Schiller NB, Botvinick E, Tyberg JV, Parmley WW, Chatterjee K. Volume loading improves low cardiac output in experimental right ventricular infarction. Journal of the American College of Cardiology 1983. PMID: 6223062


  147. Herfkens RJ, Higgins CB, Hricak H, Lipton MJ, Crooks LE, Lanzer P, Botvinick E, Brundage B, Sheldon PE, Kaufman L. Nuclear magnetic resonance imaging of the cardiovascular system: normal and pathologic findings. Radiology 1983. PMID: 6601813


  148. Botvinick EH, Perez-Gonzalez JF, Dunn R, Ports T, Chatterjee K, Parmley W. Late prognostic value of scintigraphic parameters of acute myocardial infarction size in complicated myocardial infarction without heart failure. The American journal of cardiology 1983. PMID: 6301256


  149. Schwartz AB, Donmichael TA, Botvinick EH, Ishimori T, Parmley WW, Chatterjee K. Variability in coronary hemodynamics in response to ergonovine in patients with normal coronary arteries and atypical chest pain. Journal of the American College of Cardiology 1983. PMID: 6826971


  150. Sung RJ, Shen EN, Morady F, Scheinman MM, Hess D, Botvinick EH. Electrophysiologic mechanism of exercise-induced sustained ventricular tachycardia. The American journal of cardiology 1983. PMID: 6823868


  151. Botvinick EH, Glazer HB, Shosa DW. What is the reliability and the utility of scintigraphic methods for the assessment of ventricular function? Cardiovascular clinics 1983. PMID: 6216951


  152. Hlatky M, Botvinick E, Brundage B. The independent value of exercise thallium scintigraphy to physicians. Circulation 1982. PMID: 7127707


  153. Perez-Gonzalez J, Botvinick EH, Dunn R, Rahimtoola S, Ports T, Chatterjee K, Parmley WW. The late prognostic value of acute scintigraphic measurement of myocardial infarction size. Circulation 1982. PMID: 6290099


  154. Botvinick EH, Frais MA, Shosa DW, O'Connell JW, Pacheco-Alvarez JA, Scheinman M, Hattner RS, Morady F, Faulkner DB. An accurate means of detecting and characterizing abnormal patterns of ventricular activation by phase image analysis. The American journal of cardiology 1982. PMID: 6285685


  155. Frais MA, Botvinick EH, Shosa DW, O'Connell WJ, Scheinman MM, Hattner RS, Morady F. Phase image characterization of ventricular contraction in left and right bundle branch block. The American journal of cardiology 1982. PMID: 7091010


  156. Hlatky M, Botvinick E, Brundage B. Diagnostic accuracy of cardiologists compared with probability calculations using Bayes' rule. The American journal of cardiology 1982. PMID: 7081073


  157. Topol EJ, Goldschlager N, Ports TA, Dicarlo LA, Schiller NB, Botvinick EH, Chatterjee K. Hemodynamic benefit of atrial pacing in right ventricular myocardial infarction. Annals of internal medicine 1982. PMID: 7073152


  158. Dunn RF, Botvinick EH, Benge W, Chatterjee K, Parmley WW. The significance of nitroglycerin-induced changes in ventricular function after acute myocardial infarction. The American journal of cardiology 1982. PMID: 6805287


  159. Frais M, Botvinick E, Shosa D, O'Connell W. Are regions of ischaemia detected on stress perfusion scintigraphy predictive of sites of subsequent myocardial infarction? British heart journal 1982. PMID: 7066121


  160. Botvinick E, Dunn R, Frais M, O'Connell W, Shosa D, Herfkens R, Scheinman M. The phase image: its relationship to patterns of contraction and conduction. Circulation 1982. PMID: 7055877


  161. Seder JS, Botvinick EH, Rahimtoola SH, Goldstone J, Price DC. Detecting and localizing peripheral arterial disease: assessment of 201Tl scintigraphy. AJR. American journal of roentgenology 1981. PMID: 6789648


  162. Dunn RF, Wolff L, Wagner S, Botvinick EH. The inconsistent pattern of thallium defects: a clue to the false positive perfusion scintigram. The American journal of cardiology 1981. PMID: 7270432


  163. Massie B, Botvinick E, Arnold S, Shames D, Brundage B, Hanlon JT, Sheldon K. Contrast enhancement of thallium-201 myocardial scintigrams: improved sensitivity with diminished specificity in coronary disease detection. American heart journal 1981. PMID: 7246411


  165. Greenberg BH, Drew D, Botvinick EH, Werner JA, Klausner SC, Shames DM, Parmley WW. Evaluation of left ventricular performance by gated radionuclide angiography. Clinical nuclear medicine 1980. PMID: 7379421


  167. Botvinick EH. Myocardial perfusion scintigraphy. Archives of internal medicine 1980. PMID: 7352811


  168. Massie BM, Botvinick EH, Brundage BH. Correlation of thallium-201 scintigrams with coronary anatomy: factors affecting region by region sensitivity. The American journal of cardiology 1979. PMID: 484492


  169. Schiller NB, Acquatella H, Ports TA, Drew D, Goerke J, Ringertz H, Silverman NH, Brundage B, Botvinick EH, Boswell R, Carlsson E, Parmley WW. Left ventricular volume from paired biplane two-dimensional echocardiography. Circulation 1979. PMID: 455617


  171. Massie BM, Botvinick EH, Werner JA, Chatterjee K, Parmley WW. Myocardial scintigraphy with technetium-99m stannous pyrophosphate: an insensitive test for nontransmural myocardial infarction. The American journal of cardiology 1979. PMID: 760473


  172. Massie BM, Botvinick EH, Brundage BH, Greenberg B, Shames D, Gelberg H. Relationship of regional myocardial perfusion to segmental wall motion: a physiologic basis for understanding the presence and reversibility of asynergy. Circulation 1978. PMID: 709771


  173. Schor RA, Massie BM, Botvinick EH, Shames DM. Gallium-67 uptake in silent myocardial infarction: a case report. Radiology 1978. PMID: 693859


  174. Botvinick EH, Shames DM, Sharpe DN, Klausner SC, Werner JA, Chatterjee K, Parmley WW. The specificity of pyrophosphate myocardial scintigrams in patients with prior myocardial infarction: concise communication. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1978. PMID: 214527


  175. Greenberg BH, Massie BM, Brundage BH, Botvinick EH, Parmley WW, Chatterjee K. Beneficial effects of hydralazine in severe mitral regurgitation. Circulation 1978. PMID: 668075


  176. Greenberg BH, Hart R, Botvinick EH, Werner JA, Brundage BH, Shames DM, Chatterjee K, Parmley WW. Thallium-201 myocardial perfusion scintigraphy to evaluate patients after coronary bypass surgery. The American journal of cardiology 1978. PMID: 308304


  177. Sharpe DN, Botvinick EH, Shames DM, Schiller NB, Massie BM, Chatterjee K, Parmley WW. The noninvasive diagnosis of right ventricular infarction. Circulation 1978. PMID: 624158


  178. Sharpe DN, Botvinick EH, Shames DM, Norman A, Chatterjee K, Parmley WW. The clinical estimation of acute myocardial infarct size with 99mTechnetium pyrophosphate scintigraphy. Circulation 1978. PMID: 618619


  180. Botvinick EH, Shames D, Parmley WW. Myocardial scintigraphy in coronary artery disease. Cleveland Clinic quarterly 1978. PMID: 647936


  181. Botvinick EH, Taradash MR, Shames DM, Parmley WW. Thallium-20 1 myocardial perfusion scintigraphy for the clinical clarification of normal, abnormal and equivocal electrocardiographic stress tests. The American journal of cardiology 1978. PMID: 623004


  183. Klausner SC, Botvinick EH, Shames D, Ullyot DJ, Fishman NH, Roe BB, Ebert PA, Chatterjee K, Parmley WW. The application of radionuclide infarct scintigraphy to diagnose perioperative myocardial infarction following revascularization. Circulation 1977. PMID: 872307


  184. Botvinick EH, Shames DM, Gershengorn KM, Carlsson E, Ratshin RA, Parmley WW. Myocardial stress perfusion scintigraphy with rubidium-81 versus stress electrocardiography. The American journal of cardiology 1977. PMID: 842458


  185. Tyberg JV, Massie BM, Botvinick EH, Parmley W. The hemodynamics of coronary arterial stenosis. Cardiovascular clinics 1977. PMID: 332373


  186. Prasquier R, Taradash MR, Botvinick EH, Shames DM, Parmley WW. The specificity of the diffuse pattern of cardiac uptake in myocardial infarction imaging with technetium-99m stannous pyrophosphate. Circulation 1977. PMID: 830219


  187. Botvinick EH, Shames D, Hutchinson JC, Roe BB, Fitzpatrick M. Noninvasive diagnosis of a false left ventricular aneurysm with radioisotope gated cardiac blood pool imaging. Differentiation from true aneurysm. The American journal of cardiology 1976. PMID: 1274871


  188. Lappin HA, Botvinick EH, Parmley WW, Tyberg JV. Myocardial infarction in closed-chest dogs: a simplified method for production. Journal of applied physiology 1975. PMID: 1184523


  189. Botvinick EH, Shames D, Lappin H, Tyberg JV, Townsend R, Parmley WW. Noninvasive quantitation of myocardial infarction with technetium 99m pyrophosphate. Circulation 1975. PMID: 170018


  190. Botvinick EH, Schiller NB, Wickramasekaran R, Klausner SC, Gertz E. Echocardiographic demonstration of early mitral valve closure in severe aortic insufficiency. Its clinical implications. Circulation 1975. PMID: 1122588