Connor O'Brien, MD

Assistant Professor

Cardiology

Clinical interests: Cardiologist with expertise in echocardiography and critical care medicine. Focus on care for adults with severe cardiac dysfunction or systemic shock who need prompt treatment in intensive care.

Research interests: Translating basic science discoveries to clinical applications that improve understanding of underlying disease processes and effective treatments.

Education
06/2019 - Critical Care Medicine, Stanford University
06/2018 - Cardiovascular Medicine Fellowship, Stanford University
06/2015 - Internal Medicine Residency, Stanford University
MD, 05/2012 - , Columbia University College of Physicians and Surgeons
BA, 05/2005 - Biology and Biological Basis of Behavior, University of Pennsylvania
Honors and Awards
  • Timothy F Beckett Award, Stanford University, 2020
  • Gerald Reaven Award in Basic Science, Stanford University, 2018
  • Ruth L Kirschstein National Research Service Award, National Institutes of Health, 2017-2019
  • Best Clinical Fellow Award, Stanford University, 2017
  • Timothy F Beckett Award, Stanford University, 2016
  • Johnson and Johnson Fellowship in Global Health, Stanford University, 2013-2015
  • Benjamin Kean Fellowship, American Society of Tropical Medicine and Hygiene, 2012
  • Conrad George Lattes Fellowship, Columbia University, 2012
  • Alpha Omega Alpha, Columbia University, 2011
  • Gold Humanism Society Award, Columbia University, 2011
  • Elliot Stellar Chance Award, University of Pennsylvania, 2005
Publications

  1. O'Brien CG, Brusca SB, Barnett CF, Berg DD, Baird-Zars VM, Park JG, Bohula EA, Morrow DA, CCCTN Investigators. Using Selection Criteria From the DanGer Shock Trial in a Contemporary Cohort With Cardiogenic Shock. Journal of the American College of Cardiology 2024. PMID: 39387763


  2. Patel SM, Berg DD, Bohula EA, Baird-Zars VM, Barsness GW, Chaudhry SP, Chonde MD, Cooper HA, Ginder C, Jentzer JC, Kontos MC, Miller PE, Newby LK, O'Brien CG, Park JG, Pierce MJ, Pisani BA, Potter BJ, Shah KS, Teuteberg JJ, Katz JN, van Diepen S, Morrow DA. Early Serial Assessment of Aggregate Vasoactive Support and Mortality in Cardiogenic Shock: Insights From the Critical Care Cardiology Trials Network Registry. Circulation. Heart failure 2024. PMID: 38587438


  3. Donnelly S, Barnett CF, Bohula EA, Chaudhry SP, Chonde MD, Cooper HA, Daniels LB, Dodson MW, Gerber D, Goldfarb MJ, Guo J, Kontos MC, Liu S, Luk AC, Menon V, O'Brien CG, Papolos AI, Pisani BA, Potter BJ, Prasad R, Schnell G, Shah KS, Sridharan L, So DYF, Teuteberg JJ, Tymchak WJ, Zakaria S, Katz JN, Morrow DA, van Diepen S. Interhospital Variation in Admissions Managed With Critical Care Therapies or Invasive Hemodynamic Monitoring in Tertiary Cardiac Intensive Care Units: An Analysis From the Critical Care Cardiology Trials Network Registry. Circulation. Cardiovascular quality and outcomes 2024. PMID: 38179787


  4. Berg DD, Kaur G, Bohula EA, Baird-Zars VM, Alviar CL, Barnett CF, Barsness GW, Burke JA, Chaudhry SP, Chonde M, Cooper HA, Daniels LB, Dodson MW, Gerber DA, Ghafghazi S, Gidwani UK, Goldfarb MJ, Guo J, Hillerson D, Kenigsberg BB, Kochar A, Kontos MC, Kwon Y, Lopes MS, Loriaux DB, Miller PE, O'Brien CG, Papolos AI, Patel SM, Pisani BA, Potter BJ, Prasad R, Rowsell RO, Shah KS, Sinha SS, Smith TD, Solomon MA, Teuteberg JJ, Thompson AD, Zakaria S, Katz JN, van Diepen S, Morrow DA. Prognostic Significance of Hemodynamic Parameters in Patients with Cardiogenic Shock. European heart journal. Acute cardiovascular care 2023. PMID: 37640029


  5. Kadosh BS, Berg DD, Bohula EA, Park JG, Baird-Zars VM, Alviar C, Alzate J, Barnett CF, Barsness GW, Burke J, Chaudhry SP, Daniels LB, DeFilippis A, Delicce A, Fordyce CB, Ghafghazi S, Gidwani U, Goldfarb M, Katz JN, Keeley EC, Kenigsberg B, Kontos MC, Lawler PR, Leibner E, Menon V, Metkus TS, Miller PE, O'Brien CG, Papolos AI, Prasad R, Shah KS, Sinha SS, Snell RJ, So D, Solomon MA, Ternus BW, Teuteberg JJ, Toole J, van Diepen S, Morrow DA, Roswell RO. Pulmonary Artery Catheter Use and Mortality in the Cardiac Intensive Care Unit. JACC. Heart failure 2023. PMID: 37318422


  6. Metkus T, Alviar C, Baird-Zars V, et al.. Presentation and Outcomes of Patients With Preoperative Critical Illness Undergoing Cardiac Surgery JACC advances 2023. PMID:


  7. Metkus TS, Baird-Zars VM, Alfonso CE, Alviar CL, Barnett CF, Barsness GW, Berg DD, Bertic M, Bohula EA, Burke J, Burstein B, Chaudhry SP, Cooper HA, Daniels LB, Fordyce CB, Ghafghazi S, Goldfarb M, Katz JN, Keeley EC, Keller NM, Kenigsberg B, Kontos MC, Kwon Y, Lawler PR, Leibner E, Liu S, Menon V, Miller PE, Newby LK, O'Brien CG, Papolos AI, Pierce MJ, Prasad R, Pisani B, Potter BJ, Roswell RO, Sinha SS, Shah KS, Smith TD, Snell RJ, So D, Solomon MA, Ternus BW, Teuteberg JJ, van Diepen S, Zakaria S, Morrow DA. Critical Care Cardiology Trials Network (CCCTN): a cohort profile. European heart journal. Quality of care & clinical outcomes 2022. PMID: 36029517


  8. Collins WJ, Chang AY, Weng Y, Dahlen A, O'Brien CG, Hom J, Ahuja N, Rodriguez F, Rohatgi N. Association between Obesity and Length of COVID-19 Hospitalization: Unexpected Insights from the American Heart Association National COVID-19 Registry. Journal of obesity & metabolic syndrome 2022. PMID: 36058896


  9. Vasti EC MD, MPH; Ashland MD MS, O'Donnell C MD; Rodriguez F MD, MPH; Wang P MD; O'Brien CG MD. Impact of Bradyarrhythmias Requiring Pacing on Outcomes in Patients With COVID-19 Impact of Bradyarrhythmias Requiring Pacing on Outcomes in Patients With COVID-19 2022. PMID:


  10. Brusca SB, Caughron H, Njoroge JN, Cheng R, O'Brien CG, Barnett CF. The shock team: a multidisciplinary approach to early patient phenotyping and appropriate care escalation in cardiogenic shock. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35612936


  11. O'Brien CG, Barnett CF, Dudzinski DM, Sanchez PA, Katz JN, Harold JG, Hennessey EK, Mohabir PK. Training in Critical Care Cardiology Within Critical Care Medicine Fellowship: A Novel Pathway. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35144752


  12. Barnett CF, O'Brien C, De Marco T. Critical care management of the patient with pulmonary hypertension. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 34966914


  13. O'Donnell C, Ashland MD, Vasti EC, Lu Y, Chang AY, Wang P, Daniels LB, de Lemos JA, Morrow DA, Rodriguez F, O'Brien CG. N-Terminal Pro-B-Type Natriuretic Peptide as a Biomarker for the Severity and Outcomes With COVID-19 in a Nationwide Hospitalized Cohort. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34889112


  14. O'Brien CG, Ozen MO, Ikeda G, Vaskova E, Jung JH, Bayardo N, Santoso MR, Shi L, Wahlquist C, Jiang Z, Jung Y, Zeng Y, Egan E, Sinclair R, Gee A, Witteles R, Mercola M, Svensson KJ, Demirci U, Yang PC. Mitochondria-Rich Extracellular Vesicles Rescue Patient-Specific Cardiomyocytes From Doxorubicin Injury: Insights Into the SENECA Trial. JACC. CardioOncology 2021. PMID: 34604804


  15. O'Donnell C, Rodriguez AJ, Madhok J, Sharifi H, Wang H, O'Brien CG, Boyd J, Hiesinger W, Hsu J, Hill CC. The Use of Factor Eight Inhibitor Bypass Activity (FEIBA) for the Treatment of Perioperative Hemorrhage in Left Ventricular Assist Device Implantation. Journal of cardiothoracic and vascular anesthesia 2021. PMID: 34034934


  16. Bolli R, Mitrani RD, Hare JM, Pepine CJ, Perin EC, Willerson JT, Traverse JH, Henry TD, Yang PC, Murphy MP, March KL, Schulman IH, Ikram S, Lee DP, O'Brien C, Lima JA, Ostovaneh MR, Ambale-Venkatesh B, Lewis G, Khan A, Bacallao K, Valasaki K, Longsomboon B, Gee AP, Richman S, Taylor DA, Lai D, Sayre SL, Bettencourt J, Vojvodic RW, Cohen ML, Simpson L, Aguilar D, Loghin C, Moyé L, Ebert RF, Davis BR, Simari RD, Cardiovascular Cell Therapy Research Network (CCTRN). A Phase II Study of Autologous Mesenchymal Stromal Cells and c-kit Positive Cardiac Cells, Alone or in Combination, in Patients with Ischemic Heart Failure: The CCTRN CONCERT-HF Trial. European journal of heart failure 2021. PMID: 33811444


  17. Jung JH, Ikeda G, Tada Y, von Bornstädt D, Santoso MR, Wahlquist C, Rhee S, Jeon YJ, Yu AC, O'brien CG, Red-Horse K, Appel EA, Mercola M, Woo J, Yang PC. miR-106a-363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3 pathway in ischemic heart injury. Basic research in cardiology 2021. PMID: 33742276


  18. Ikeda G, Santoso MR, Tada Y, Li AM, Vaskova E, Jung JH, O'Brien C, Egan E, Ye J, Yang PC. Mitochondria-Rich Extracellular Vesicles From Autologous Stem Cell-Derived Cardiomyocytes Restore Energetics of Ischemic Myocardium. Journal of the American College of Cardiology 2021. PMID: 33632482


  19. Coromilas EJ, Kochav S, Goldenthal I, Biviano A, Garan H, Goldbarg S, Kim JH, Yeo I, Tracy C, Ayanian S, Akar J, Singh A, Jain S, Zimerman L, Pimentel M, Osswald S, Twerenbold R, Schaerli N, Crotti L, Fabbri D, Parati G, Li Y, Atienza F, Zatarain E, Tse G, Leung KSK, Guevara-Valdivia ME, Rivera-Santiago CA, Soejima K, De Filippo P, Ferrari P, Malanchini G, Kanagaratnam P, Khawaja S, Mikhail GW, Scanavacca M, Hajjar LA, Rizerio Gomes B, Sacilotto L, Mollazadeh R, Eslami M, Laleh Far V, Mattioli AV, Boriani G, Migliore F, Cipriani A, Donato F, Compagnucci P, Casella M, Dello Russo A, Coromilas J, Aboyme A, O'Brien CG, Rodriguez F, Wang PJ, Naniwadekar A, Moey M, Know CS, Cheah WK, Auricchio A, Conte G, Hwang J, Han S, Lazzerini PE, Franchi F, Santoro A, Capecchi PL, Joglar JA, Rosenblatt AG, Zardini M, Bricoli S, Bonura R, Echarte-Morales J, Benito-González T, Minguito-Carazo C, Fernández-Vázquez F, Wan EY. Worldwide Survey of COVID-19 Associated Arrhythmias. Circulation. Arrhythmia and electrophysiology 2021. PMID: 33554620


  20. Bolli R, Perin EC, Willerson JT, Yang PC, Traverse JH, Henry TD, Pepine CJ, Mitrani RD, Hare JM, Murphy MP, March KL, Ikram S, Lee DP, O'Brien C, Durand JB, Miller K, Lima JA, Ostovaneh MR, Ambale-Venkatesh B, Gee AP, Richman S, Taylor DA, Sayre SL, Bettencourt J, Vojvodic RW, Cohen ML, Simpson LM, Lai D, Aguilar D, Loghin C, Moyé L, Ebert RF, Davis BR, Simari RD. Allogeneic Mesenchymal Cell Therapy in Anthracycline-Induced Cardiomyopathy Heart Failure Patients: The CCTRN SENECA Trial. JACC. CardioOncology 2020. PMID: 33403362


  21. O'Brien C, Ning N, McAvoy J, Mitchell JE, Kalwani N, Wang P, Nguyen D, Reejhsinghani R, Rogers A, Lorenzo J. Electrical Storm in COVID-19. Volume 2 of Issue 9. 2020. PMID: 32835266


  22. Katz JN, Sinha SS, Alviar CL, Dudzinski DM, Gage A, Brusca SB, Flanagan MC, Welch T, Geller BJ, Miller PE, Leonardi S, Bohula EA, Price S, Chaudhry SP, Metkus TS, O'Brien CG, Sionis A, Barnett CF, Jentzer JC, Solomon MA, Morrow DA, van Diepen S. COVID-19 and Disruptive Modifications to Cardiac Critical Care Delivery: JACC Review Topic of the Week. Volume 76 of Issue 1. Journal of the American College of Cardiology 2020. PMID: 32305402


  23. O'Brien C, Beaubien-Souligny W, Amsallem M, Denault A, Haddad F. Cardiogenic Shock: Reflections at the Crossroad Between Perfusion, Tissue Hypoxia, and Mitochondrial Function. Volume 36 of Issue 2. 2019. PMID: 32036863


  24. Perez MV, Mahaffey KW, Hedlin H, Rumsfeld JS, Garcia A, Ferris T, Balasubramanian V, Russo AM, Rajmane A, Cheung L, Hung G, Lee J, Kowey P, Talati N, Nag D, Gummidipundi SE, Beatty A, Hills MT, Desai S, Granger CB, Desai M, Turakhia MP. Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation. Volume 381 of Issue 20. The New England journal of medicine 2019. PMID: 31722151


  25. Yang D, O'Brien CG, Ikeda G, Traverse JH, Taylor DA, Henry TD, Bolli R, Yang PC. Meta-analysis of short- and long-term efficacy of mononuclear cell transplantation in patients with myocardial infarction. Volume 220. American heart journal 2019. PMID: 31821904


  27. Chaung KT, O'Brien C, Ha NB, Nguyen NH, Trinh HN, Nguyen MH. Alternative Therapies for Chronic Hepatitis B Patients With Partial Virological Response to Standard Entecavir Monotherapy. Volume 50 of Issue 4. Journal of clinical gastroenterology 2016. PMID: 26646801


  28. Neofytou E, O'Brien CG, Couture LA, Wu JC. Hurdles to clinical translation of human induced pluripotent stem cells. Volume 125 of Issue 7. The Journal of clinical investigation 2015. PMID: 26132109


  29. Uribe LA, O'Brien CG, Wong RJ, Gish RR, Tsai N, Nguyen MH. Current treatment guidelines for chronic hepatitis B and their applications. Volume 48 of Issue 9. Journal of clinical gastroenterology 2014. PMID: 24859715


  30. Henrich PP, O'Brien C, Sáenz FE, Cremers S, Kyle DE, Fidock DA. Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model. Volume 58 of Issue 1. Antimicrobial agents and chemotherapy 2013. PMID: 24145526


  31. Safe IP, O'brien C, Ferreira FR, Souza ML, Ramasawmy R. Tuberculosis associated with transient hemolytic anemia responsive to tuberculosis chemotherapy: a case report. Volume 17 of Issue 1. 2013. PMID: 23290474


  32. Lança EF, Magalhães BM, Vitor-Silva S, Siqueira AM, Benzecry SG, Alexandre MA, O'Brien C, Bassat Q, Lacerda MV. Risk factors and characterization of Plasmodium vivax-associated admissions to pediatric intensive care units in the Brazilian Amazon. Volume 7 of Issue 4. PloS one 2012. PMID: 22523591


  33. Brasil LW, Areas AL, Melo GC, Oliveira CM, Alecrim MG, Lacerda MV, O'Brien C, Oelemann WM, Zalis MG. Pfatp6 molecular profile of Plasmodium falciparum isolates in the western Brazilian Amazon. Volume 11. 2012. PMID: 22487143


  34. O'Brien C, Henrich PP, Passi N, Fidock DA. Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum. Volume 24 of Issue 6. 2011. PMID: 22001944


  35. Fitzgerald JT, Henrich PP, O'Brien C, Krause M, Ekland EH, Mattheis C, Sá JM, Fidock D, Khosla C. In vitro and in vivo activity of frenolicin B against Plasmodium falciparum and P berghei. Volume 64 of Issue 12. 2011. PMID: 22008701


  36. Pereira MR, Henrich PP, Sidhu AB, Johnson D, Hardink J, Van Deusen J, Lin J, Gore K, O'Brien C, Wele M, Djimde A, Chandra R, Fidock DA. In vivo and in vitro antimalarial properties of azithromycin-chloroquine combinations that include the resistance reversal agent amlodipine. Volume 55 of Issue 7. Antimicrobial agents and chemotherapy 2011. PMID: 21464242