Arun Padmanabhan, MD, PhD

Assistant Professor

CLINICAL INTERESTS: Dr. Padmanabhan is a cardiologist specializing in general cardiology. His specific interests include preventive cardiology, lamin A/C gene (LMNA) associated cardiomyopathies, and right heart disease in athletes.

RESEARCH INTERESTS: Dr. Padmanabhan’s research focuses on understanding the gene-regulatory and epigenetic pathways that govern cell fate decisions during early cardiac development and cell state transitions in the pathophysiology of heart failure.
2017 - Cardiovascular Disease Fellowship, University of California San Francisco
2014 - Internal Medicine Residency, Massachusetts General Hospital, Harvard Medical School
M.D., 2012 - , University of Pennsylvania
Ph.D., 2010 - Cell & Developmental Biology, University of Pennsylvania
A.B., 2003 - Biochemistry & Molecular Biology, Washington University in St. Louis
  1. Chorba JS, Xia VQ, Smith GA, Padmanabhan A. Rapid Multiplexed Flow Cytometric Validation of CRISPRi sgRNAs in Tissue Culture. Bio-protocol 2023. PMID: 36789164

  2. Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Lee CY, Sadagopan N, Huang Y, Pelonero A, Auclair K, Zhu A, Gonzalez Teran B, Flanigan W, Kim CK, Lumbao-Conradson K, Costa M, Jain R, Charo I, Haldar SM, Pollard KS, Vagnozzi RJ, McKinsey TA, Przytycki PF, Srivastava D. Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis. bioRxiv : the preprint server for biology 2023. PMID: 36711864

  3. Smith GA, Padmanabhan A, Lau BH, Pampana A, Li L, Lee CY, Pelonero A, Nishino T, Sadagopan N, Xia VQ, Jain R, Natarajan P, Wu RS, Black BL, Srivastava D, Shokat KM, Chorba JS. Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor. Science translational medicine 2022. PMID: 36103516

  4. Zhu L, Choudhary K, Gonzalez-Teran B, Ang YS, Thomas R, Stone NR, Liu L, Zhou P, Zhu C, Ruan H, Huang Y, Jin S, Pelonero A, Koback F, Padmanabhan A, Sadagopan N, Hsu A, Costa MW, Gifford CA, van Bemmel JG, Hüttenhain R, Vedantham V, Conklin BR, Black BL, Bruneau BG, Steinmetz L, Krogan NJ, Pollard KS, Srivastava D. Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors. Circulation 2022. PMID: 35938400

  5. Hsu A, Duan Q, Day DS, Luo X, McMahon S, Huang Y, Feldman ZB, Jiang Z, Zhang T, Liang Y, Alexanian M, Padmanabhan A, Brown JD, Lin CY, Gray NS, Young RA, Bruneau BG, Haldar SM. Targeting transcription in heart failure via CDK7/12/13 inhibition. Nature communications 2022. PMID: 35896549

  6. Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Hüttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, McGregor M, Gifford CA, Seidman JG, Seidman CE, Gelb BD, Colombo G, Conklin BR, Black BL, Bruneau BG, Krogan NJ, Pollard KS, Srivastava D. Transcription factor protein interactomes reveal genetic determinants in heart disease. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022. PMID: 35182466

  7. Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R. Publisher Correction: BRD4 orchestrates genome folding to promote neural crest differentiation. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34725478

  8. Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R. BRD4 orchestrates genome folding to promote neural crest differentiation. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021. PMID: 34611363

  9. Mellis IA, Edelstein HI, Truitt R, Goyal Y, Beck LE, Symmons O, Dunagin MC, Linares Saldana RA, Shah PP, Pérez-Bermejo JA, Padmanabhan A, Yang W, Jain R, Raj A. Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro. Cell systems 2021. PMID: 34352221

  10. Alexanian M, Przytycki PF, Micheletti R, Padmanabhan A, Ye L, Travers JG, Gonzalez-Teran B, Silva AC, Duan Q, Ranade SS, Felix F, Linares-Saldana R, Li L, Lee CY, Sadagopan N, Pelonero A, Huang Y, Andreoletti G, Jain R, McKinsey TA, Rosenfeld MG, Gifford CA, Pollard KS, Haldar SM, Srivastava D. A transcriptional switch governs fibroblast activation in heart disease. Nature 2021. PMID: 34163071

  11. Padmanabhan A, Alexanian M, Linares-Saldana R, González-Terán B, Andreoletti G, Huang Y, Connolly AJ, Kim W, Hsu A, Duan Q, Winchester SAB, Felix F, Perez-Bermejo JA, Wang Q, Li L, Shah PP, Haldar SM, Jain R, Srivastava D. BRD4 Interacts with GATA4 to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes. Circulation 2020. PMID: 33094644

  12. Padmanabhan A, Haldar SM. Drugging transcription in heart failure. The Journal of physiology 2019. PMID: 30927446

  13. Alexanian M, Padmanabhan A, McKinsey TA, Haldar SM. Epigenetic therapies in heart failure. Journal of molecular and cellular cardiology 2019. PMID: 30991033

  14. Muniyappa A, Padmanabhan A, Goldschlager N. A Wide Complex Tachycardia in a Woman During Exercise: Did She Tread Into Dangerous Territory? JAMA internal medicine 2018. PMID: 30419135

  15. Padmanabhan A, Haldar SM. Unusual transcription factor protects against heart failure. Science (New York, N.Y.) 2018. PMID: 30573617

  16. Cedarbaum ER, Padmanabhan A, Goldschlager N. Electrical Alternans in Disguise-A Curious Case of Atrial Flutter. JAMA internal medicine 2018. PMID: 30383080

  17. Morehead-Gee A, Padmanabhan A, Goldschlager N. Not Your Typical ST-Elevation Myocardial Infarction. Volume 178 of Issue 2. JAMA internal medicine 2018. PMID: 29159403

  18. Padmanabhan A, Haldar SM. Plasma MicroRNA Clusters in Human Left Ventricular Remodeling: A Biomarker and Discovery Platform. Volume 11 of Issue 2. 2018. PMID: 29438983

  19. Yzaguirre AD, Padmanabhan A, de Groh ED, Engleka KA, Li J, Speck NA, Epstein JA. Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos. Volume 4. 2015. PMID: 26460546

  20. Jain R, Li D, Gupta M, Manderfield LJ, Ifkovits JL, Wang Q, Liu F, Liu Y, Poleshko A, Padmanabhan A, Raum JC, Li L, Morrisey EE, Lu MM, Won KJ, Epstein JA. HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts. Volume 348 of Issue 6242. 2015. PMID: 26113728

  21. Jain R, Barkauskas CE, Takeda N, Bowie EJ, Aghajanian H, Wang Q, Padmanabhan A, Manderfield LJ, Gupta M, Li D, Li L, Trivedi CM, Hogan BL, Epstein JA. Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. Volume 6. 2015. PMID: 25865356

  22. Vaduganathan M, Nagarur A, Kerr DA, Lauter KB, Padmanabhan A, Raghavan S, Pallais JC, Fenves AZ. Metastatic pancreatic neuroendocrine tumor with ectopic adrenocorticotropic hormone production. Volume 28 of Issue 1. 2015. PMID: 25552797

  23. Padmanabhan A, Haldar SM. Neuroprotection in ischemic stroke: AhR we making progress? Volume 130 of Issue 23. Circulation 2014. PMID: 25359167

  24. Takeda N, Jain R, Leboeuf MR, Padmanabhan A, Wang Q, Li L, Lu MM, Millar SE, Epstein JA. Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells. Volume 140 of Issue 8. 2013. PMID: 23487314

  25. Shin J, Padmanabhan A, de Groh ED, Lee JS, Haidar S, Dahlberg S, Guo F, He S, Wolman MA, Granato M, Lawson ND, Wolfe SA, Kim SH, Solnica-Krezel L, Kanki JP, Ligon KL, Epstein JA, Look AT. Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. Volume 5 of Issue 6. 2012. PMID: 22773753

  26. Zhu C, Smith T, McNulty J, Rayla AL, Lakshmanan A, Siekmann AF, Buffardi M, Meng X, Shin J, Padmanabhan A, Cifuentes D, Giraldez AJ, Look AT, Epstein JA, Lawson ND, Wolfe SA. Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish. Volume 138 of Issue 20. 2011. PMID: 21937602

  27. Lee JS, Padmanabhan A, Shin J, Zhu S, Guo F, Kanki JP, Epstein JA, Look AT. Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene. Volume 19 of Issue 23. 2010. PMID: 20858602

  28. Elden AC, Kim HJ, Hart MP, Chen-Plotkin AS, Johnson BS, Fang X, Armakola M, Geser F, Greene R, Lu MM, Padmanabhan A, Clay-Falcone D, McCluskey L, Elman L, Juhr D, Gruber PJ, Rüb U, Auburger G, Trojanowski JQ, Lee VM, Van Deerlin VM, Bonini NM, Gitler AD. Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Volume 466 of Issue 7310. 2010. PMID: 20740007

  29. Degenhardt K, Wright AC, Horng D, Padmanabhan A, Epstein JA. Rapid 3D phenotyping of cardiovascular development in mouse embryos by micro-CT with iodine staining. Volume 3 of Issue 3. 2010. PMID: 20190279

  30. Degenhardt KR, Milewski RC, Padmanabhan A, Miller M, Singh MK, Lang D, Engleka KA, Wu M, Li J, Zhou D, Antonucci N, Li L, Epstein JA. Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions. Volume 339 of Issue 2. 2010. PMID: 20045680

  31. Padmanabhan A, Lee JS, Ismat FA, Lu MM, Lawson ND, Kanki JP, Look AT, Epstein JA. Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI. Volume 106 of Issue 52. Proceedings of the National Academy of Sciences of the United States of America 2009. PMID: 19966217

  32. Caporini MA, Padmanabhan A, Cardon TB, Lorigan GA. Investigating magnetically aligned phospholipid bilayers with various lanthanide ions for X-band spin-label EPR studies. Volume 1612 of Issue 1. Biochimica et biophysica acta 2003. PMID: 12729929

  33. Cardon TB, Tiburu EK, Padmanabhan A, Howard KP, Lorigan GA. Magnetically aligned phospholipid bilayers at the parallel and perpendicular orientations for X-band spin-label EPR studies. Volume 123 of Issue 12. 2001. PMID: 11456991