Selected Publications

  1. Zhang Y, Takagawa J, Sievers RE, Khan MF, Viswanathan MN, Springer ML, Foster E, Yeghiazarians Y. Validation of the wall motion score and myocardial performance indexes as novel techniques to assess left ventricular function in mice after myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H1187-92. PMID: 17028161
  2. Takagawa J. Zhang Y, Sievers RE, Kapasi NK, Wong ML, Wang Y, Yeghiazarians Y, Lee RJ, Grossman W, Springer ML. Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches. J Appl Physiol. 2007 Jun;102(6):2104-11. PMC2675697
  3. Fan Y, Ye J, Shen F,Zhu Y, Yeghiazarians Y, Chen Y, Lawton MT, Young WL, Yang GY. IL-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro. J Cereb Blood Flow Metab. 2008 Jan;28(1):90-8. PMC2581498
  4. Heiss C, Wong ML, Block VI, Lao D, Real WM, Yeghiazarians Y, Lee RJ, Springer ML. Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cells. J Cell Physiol. 2008 May;215(2):366-73. PMC2835212
  5. Yeghiazarians Y, Zhang Y, Prasad M, Shih H, Saini SA, Takagawa J, Sievers RE, Wong ML, Kapasi NK, Mirsky R, Koskenvuo J, Minasi P, Ye J, Viswanathan MN, Angeli FS, Boyle AJ, Springer ML, Grossman W. Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy. Mol Ther. 2009 July;107(17):1250-6. PMID: 19384293
  6. Yeghiazarians Y, Khan M, Angeli FS, Zhang Y, Jahn S, Prasad M, Mirsky R, Shih H, Minasi P, Boyle A, Grossman W. Cytokine combination therapy with long-acting erythropoetin and granulocyte colony stimulating factor improves cardiac function but is not superior than monotherapy in a mouse model of acute myocardial infarction. J Cardiac Fail. 2010 Aug;16(8):669-78. PMID: 20670846
  7. Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabil N, Prasad M, Rassaf T, Ottaviani JI, Mihardja S, Keen CL, Springer ML, Boyle A, Grossman W, Glantz SA, Schroeter H, Yeghiazarians Y. Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. J Am Coll Cardiol. 2010 Jul 13;56(3):218-24. PMID: 20620742
  8. Gaur M, Ritner C, Sievers R, Pedersen A, Prasad M, Bernstein H, Yeghiazarians Y. Timed inhibition of p38MAPK directs accelerated differentiation of human embryonic stem cells into cardiomyocytes. Cytotherapy. 2010 Oct; 12(6):807-17.
  9. Zhang Y, Sievers RE, Prasad M, Mirsky R, Shih H, Wong ML, Angeli FS, Ye J, Takagawa J, Koskenvuo JW, Springer ML, Grossman W, Boyle AJ, Yeghiazarians Y. Timing of bone marrow cell therapy is more important than repeated injections after myocardial infarction. Cardiovascular Pathology. 2010 Jul 29. PMID: 20667749
  10. Boyle AJ, Shih H, Hwang J, Ye J, Lee B, Zhang Y, Kwon D, Jun K, Zheng D, Sievers R, Angeli F, Yeghiazarians Y, Lee R. Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition toward cardiomyocyte apoptosis and autophagy. Exp Gerontol. 2011 Mar 3.
  11. Mirsky R, Jahn S, Koskenvuo JW, Sievers RE, Yim SM, Ritner C, Bernstein HS, Angeli FS, Boyle AJ, DeMarco T, Yeghiazarians Y. Treatment of pulmonary arterial hypertension with circulating angiogenic cells. Am J Physiol Lung Cell Mol Physiol. 2011 Jul;301(1):L12-9.
  12. Boyle AJ, Yeghiazarians Y, Shih H, Hwang J, Ye J, Sievers R, Zheng D, Palasubramaniam J, Palasubramaniam D, Karschimkus C, Whitbourn R, Jenkins A, Wilson AM. Myocardial Production and Release of MCP-1 and SDF-1 Following Myocardial Infarction: Differences Between Mice and Man. J Transl Med. 2011. 9:150.
  13. Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers RE, Carbone L, Kogan S, Yeghiazarians Y, Hermiston ML, Springer ML. Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response. Sci Transl Med. 2011 Sep 14;3(100):100ra90. PMC3350804
  14. Wang X, Takagawa J, Haddad DJ, Pinnamaneni K, Zhang Y, Sievers RE, Grossman W, Yeghiazarians Y, Springer ML. Advanced Donor Age Impairs Bone Marrow Cell Therapeutic Efficacy for Cardiac Disease. J Tissue Sci Eng. 2011 Nov 18;S3. pii: 002
  15. Yeghiazarians Y, Meenakshi Gaur M, Yan Zhang Y, Sievers RE, Ritner C, Prasad M, Boyle A, Bernstein HS. Myocardial improvement with human embryonic stem cell-derived cardiomyocytes enriched by p38MAPK inhibition. Cytotherapy. 2012 Feb;14(2):223-31.
  16. Ye J, Boyle A, Shih H, Sievers RE, Zhang Y, Prasad M, Su H, Zhou Y, Grossman W, Bernstein HS, Yeghiazarians Y. Sca-1+ Cardiosphere-Derived Cells Are Enriched for Isl1-Expressing Cardiac Precursors and Improve Cardiac Function after Myocardial Injury. PLoS ONE. 2012;7(1):e30329.
  17. Koskenvuo JW, Sievers RE, Zhang Y, Angeli FS, Lee B, Shih H, Ye J, Boyle AJ, Yeghiazarians Y. Fractionation of mouse bone marrow cells limits functional efficacy in non-reperfused mouse model of acute myocardial infarction. Ann Med. 2012 Dec;44(8):829-35.
  18. Angeli FS, Zhang Y, Sievers R, Jun K, Yim S, Boyle A, Yeghiazarians Y. Injection of human bone marrow and mononuclear cell extract into infarcted mouse hearts results in functional improvement. Open Cardiovasc Med J. 2012;6:38-43.
  19. Ye J, Boyle AJ, Shih H, Sievers RE, Wang ZE, Gormley M, Yeghiazarians Y. CD45-positive cells are not an essential component in cardiosphere formation. Cell Tissue Res. 2013 Jan;351(1):201-5.
  20. Ameri K, Rajah AM, Nguyen V, Sanders TA, Jahangiri A, DeLay M, Donne M, Choi HJ, Tormos KV, Yeghiazarians Y, Jeffrey SS, Rinaudo PF, Rowitch DH, Aghi M, Maltepe E. Nuclear Localization of the Mitochondrial Factor HIGD1A During Metabolic Stress. PLoS ONE. 2013 Apr 30;8(4):e62758
  21. Boyle AJ, Hwang J, Ye J, Shih H, Jun K, Zhang Y, Fang Q, Sievers R, Yeghiazarians Y, Lee RJ. The effects of aging on apoptosis following myocardial infarction. Cardiovasc Ther 31(6):e102-10, 2013.
  22. Yeghiazarians Y, Honbo N, Imhof I, Woods B, Aguilera V, Ye J, Boyle AJ, Karliner JS. IL-15: A novel pro-survival signaling pathway in cardiomyocytes, J Cardiovasc Pharmacol 63(5):406-11, 2014. PMID: 24805144
  23. Ye J, Yeghiazarians Y. Cardiac stem cell Therapy: review of the native cardiac progenitor cells and future direction. J Cardiovasc Pharmacol 63(2):85-94, 2014. PMID: 23674056.
  24. Jha AK, Tharp KM, Ye J, Santiago-Ortiz JL, Jackson WM, Stahl A, Schaffer DV, Yeghiazarians Y, Healy KE. Enhanced survival and engraftment of transplanted stem cells using growth factor sequestering hydrogels. Biomaterials 47:1-2, 2015
  25. Ameri K, Jahangiri A, Rajah AM, Tormos KV, Nagarajan R, Pekmezci M, Nguyen V, Wheeler ML, Murphy MP, Sanders TA, Jeffrey SS, Yeghiazarians Y, Rinaudo PF, Costello JF, Aghi MK, Maltepe E. HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth. Cell Rep S2211-1247, 2015. PMID: 25683712
  26. Jha AK, Mathur A, Svedlund FL, Ye J, Yeghiazarians Y, Healy KE. Molecular weight and concentration of heparin in hyaluronic acid-based matrices modulates growth factor retention kinetics and stem cell fate. J Controlled Release. 209:308-316, 2015. PMID: 25931306
  27. Yeghiazarians Y, Harris AL, Ameri K. Definition of Anoxia. Encyclopedia of Cancer, published by Springer- Berlin/Heidelberg 2015. DOI 10.1007/978-3-642-27841-9_292-2
  28. Jha AK, Tharp KM, Browne S, Ye J, Stahl A, Yeghiazarians Y, Healy KE. Matrix metalloproteinase-13 mediated degradation of hyaluronic acid based matrices orchestrates stem cell engraftment through vascular integration. Biomaterials 89:136-47, 2016. PMID: 26967648  
  29. Ameri K, Bayardorj D, Samurkashian R, et al. Administration of Interleukin-15 Peptide Improves Cardiac Function in a Mouse Model of Myocardial Infarction. J Cardiovasc Pharmacol. 2020;75(1):98-102. 

  30. Ameri K, Samurkashian R, Yeghiazarians Y. Three-Dimensional Bioprinting: Emerging Technology in Cardiovascular Medicine. Circulation. 2017;135(14):1281-1283.