Research and Clinical Trials

Why participate in a clinical trial?

Clinical trials help to further our understanding of amyloidosis by allowing us to test the effectiveness of new therapies. Although there is currently no cure for amyloidosis, participating in a clinical trial may help to pave the way for future new treatments. If you are considering participating in a clinical trial, you should discuss the potential benefits and risks of participation with your doctor.

Amyloid Clinical Trials Open to Patients

Title of Project: Tafamidis B3461045

Principle Investigator: Teresa De Marco, MD

Sub-Investigator: Van Selby, MD

Purpose (one sentence): Phase III multicenter, randomized, double-blind extension study to evaluate the safety of daily oral dosing of tafamidis meglumine (PF-06291826) 20mg or 80 mg in subjects diagnosed with transthyretin cardiomyopathy (TTR-CM)

Sponsor or Funder: Pfizer 

https://www.clinicaltrials.gov/ct2/show/NCT02791230

Title of Project: EIDOS AG10-101

Principal Investigator: Van Selby, MD

Purpose (one sentence): Collect blood samples of different variant TTRs in the sera and plasma from ATTR patients (or relatives with different TTR genotypes) to assess the TTR binding and stabilizing properties of study drug AG10.

Sponsor or Funder : Eidos Therapeutics, Inc.

Title of Project: EIDOS AG10-201

Principal Investigator: Van Selby, MD

Purpose (one sentence): A phase II multicenter, randomized, placebo-controlled, dose-ranging study of the safety, tolerability, pharmacokinetics and pharmacodynamics of AG10 in patients with symptomatic transthyretin amyloid cardiomyopathy.

Sponsor or Funder : Eidos Therapeutics, Inc. 

https://www.clinicaltrials.gov/ct2/show/NCT03458130

Title of Project: EIDOS AG10-202

Principal Investigator: Van Selby, MD

Purpose (one sentence): Multicenter, open-label extension and safety monitoring study of patients with symptomatic transthyretin cardiomyopathy who completed the parent study AG10-201.

Sponsor or Funder : Eidos Therapeutics, Inc.

https://www.clinicaltrials.gov/ct2/show/NCT03536767

View on ClinicalTrials.gov.

If you would like to learn more or contribute to the clinical care and research activities of the Amyloid Center, please contact Melanie Ranen at [email protected] or Eileen Murphy at [email protected].